Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans
and Aureobasidium pullulans and the effect of cytoskeletal
inhibitors.

J 2001

Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors.

KOPECKÁ, Marie; Miroslav GABRIEL; Augustin SVOBODA; Kanji TAKEO; Masashi YAMAGUCHI et. al.

Basic information

Original name

Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors.

Authors

KOPECKÁ, Marie (203 Czech Republic, guarantor, belonging to the institution); Miroslav GABRIEL (203 Czech Republic, belonging to the institution); Augustin SVOBODA (203 Czech Republic, belonging to the institution); Kanji TAKEO; Masashi YAMAGUCHI; Kunihiko HATA; Soichi YOSHIDA and Misako OHKUSU

Edition

YEAST, Velká Britanie, John Wiley &Sons, Ltd. 2001, 0749-503X

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 2.540

RIV identification code

RIV/00216224:14110/01:00004386

Organization unit

Faculty of Medicine

UT WoS

000170442100357

Keywords in English

cytoskeleton; actin; microtubules; yeast human pathogens; cytoskeleton inhibitors

Abstract

In the original language

The objectives were to identify cytoskeleton and to use cytoskeletal inhibitors to arrest proliferation and induce pathogens death. C. neoformans had actin and microtubules. A. pullulans had multinuclear hyphae. Cytoplasmic microtubules disappeared before spindle formation and synchronous mitoses. Actin cables were absent, but rings and patches occurred. The polymorphy may reflect deficient actin cytoskeleton. Cytochalasin D had no effect on actin structures and proliferation of pathogens. Methylbenzimidazol-2-yl carbamate disintegrated microtubules, blocked mitoses and proliferation. As none of the drugs caused irreversible inhibition of proliferation, further cytoskeletal inhibitors will be investigated. Financial support was provided by Japanese Ministry of Education, Science and Culture for Marie Kopecká as a Guest Professor at Chiba University, Japan in 1998-1999. This project was supported by grant no. 310/00/0391 from the Grant Agency of the Czech Republic.

Links

GA310/00/0391, research and development project

Name: Cytoskelet u lidských patogenních kvasinkových mikroorganismů.

Investor: Czech Science Foundation, Cytoskeleton in human pathogenic yeast microorganisms

Cite

KOPECKÁ, Marie; Miroslav GABRIEL; Augustin SVOBODA; Kanji TAKEO; Masashi YAMAGUCHI; Kunihiko HATA; Soichi YOSHIDA and Misako OHKUSU. Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors. YEAST. Velká Britanie: John Wiley &Sons, Ltd., 2001, vol. 18, Number S1, p. S207, 2 pp. ISSN 0749-503X.

@article{367734,
   author = {Kopecká, Marie and Gabriel, Miroslav and Svoboda, Augustin and Takeo, Kanji and Yamaguchi, Masashi and Hata, Kunihiko and Yoshida, Soichi and Ohkusu, Misako},
   article_location = {Velká Britanie},
   article_number = {Number S1},
   keywords = {cytoskeleton; actin; microtubules; yeast human pathogens; cytoskeleton inhibitors},
   language = {eng},
   issn = {0749-503X},
   journal = {YEAST},
   title = {Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors.},
   volume = {18},
   year = {2001}
}

TY  - JOUR
ID  - 367734
AU  - Kopecká, Marie - Gabriel, Miroslav - Svoboda, Augustin - Takeo, Kanji - Yamaguchi, Masashi - Hata, Kunihiko - Yoshida, Soichi - Ohkusu, Misako
PY  - 2001
TI  - Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors.
JF  - YEAST
VL  - 18
IS  - Number S1
SP  - S207
EP  - S207
PB  - John Wiley &Sons, Ltd.
SN  - 0749503X
KW  - cytoskeleton
KW  - actin
KW  - microtubules
KW  - yeast human pathogens
KW  - cytoskeleton inhibitors
N2  - The objectives were to identify cytoskeleton and to use cytoskeletal inhibitors to arrest proliferation and induce pathogens death. C. neoformans had actin and microtubules. A. pullulans had multinuclear hyphae. Cytoplasmic microtubules disappeared before spindle formation and synchronous mitoses. Actin cables were absent, but rings and patches occurred. The polymorphy may reflect deficient actin cytoskeleton. Cytochalasin D had no effect on actin structures and proliferation of pathogens. Methylbenzimidazol-2-yl carbamate disintegrated microtubules, blocked mitoses and proliferation. As none of the drugs caused irreversible inhibition of proliferation, further cytoskeletal inhibitors will be investigated. Financial support was provided by Japanese Ministry of Education, Science and Culture for Marie Kopecká as a Guest Professor at Chiba University, Japan in 1998-1999. This project was supported by grant no. 310/00/0391 from the Grant Agency of the Czech Republic.
ER  -

KOPECKÁ, Marie; Miroslav GABRIEL; Augustin SVOBODA; Kanji TAKEO; Masashi YAMAGUCHI; Kunihiko HATA; Soichi YOSHIDA and Misako OHKUSU. Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors. \textit{YEAST}. Velká Britanie: John Wiley \&{}Sons, Ltd., 2001, vol.~18, Number S1, p.~S207, 2 pp. ISSN~0749-503X.

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