Changes of mouse agonistic behaviour induced by cannabinoid receptor agonist HU 210 and antagonist AM 251

VINKLEROVÁ, Jana a Alexandra ŠULCOVÁ. Changes of mouse agonistic behaviour induced by cannabinoid receptor agonist HU 210 and antagonist AM 251. Behavioural Pharmacology. London, UK: Lippincott Williams and Wilkins, 2001, roč. 12, Suppl. 1, s. 107. ISSN 0955-8810.

Základní údaje

Originální název

Changes of mouse agonistic behaviour induced by cannabinoid receptor agonist HU 210 and antagonist AM 251

Autoři

VINKLEROVÁ, Jana a Alexandra ŠULCOVÁ

Vydání

Behavioural Pharmacology, London, UK, Lippincott Williams and Wilkins, 2001, 0955-8810

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.931

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/01:00004404

Organizační jednotka

Lékařská fakulta

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Anotace

V originále

Cannabinoids are known to produce behavioural changes influencing on social interactions of the user. However, the experimental evidence in this field is rather poor. The present study investigated the influence of two cannabinoid receptor ligands on social behavioural acts in singly-housed male mice on dyadic agonistic interactions with the non-aggressive group-housed partners in neutral cages. The synthetic cannabinoid receptor agonist HU 210 caused a typical biphasic effects, low dose (0.01 mg/kg) produced stimulation of aggression in timid mice, while high doses (0.05 and 0.1 mg/kg) elicited inhibition. Cannabinoid receptor antagonist AM 251 (0.5 and 2.5 and 7.5 mg/kg) did not elicit any significant changes of the behaviour in aggressive mice, however acts pro-aggressively in timid mice.