Caffeine and A2 adenosine receptor agonist CGS1680: A comparative study of acute and chronic repeated administration effects on agonistic behaviour in mice

ŠULCOVÁ, Alexandra. Caffeine and A2 adenosine receptor agonist CGS1680: A comparative study of acute and chronic repeated administration effects on agonistic behaviour in mice. Behavioural Pharmacology. London, UK: Lippincott Williams and Wilkins, 2001, roč. 12, Suppl.1, s. S99, 2 s. ISSN 0955-8810.

Základní údaje

Originální název

Caffeine and A2 adenosine receptor agonist CGS1680: A comparative study of acute and chronic repeated administration effects on agonistic behaviour in mice

Autoři

ŠULCOVÁ, Alexandra

Vydání

Behavioural Pharmacology, London, UK, Lippincott Williams and Wilkins, 2001, 0955-8810

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.931

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/01:00004416

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Caffeine -A2 adenosine receptor agonist CGS1680 - agonistic behaviour in mice

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Anotace

V originále

Acute caffeine doses (25 and 75 mg/kg) significantly and selectively increased aggressivity while CGS21680 (0.1 and 0.5 mg/kg) markedly inhibited aggressive acts and increased defensive-escape behaviour. Repeated administration treatment with caffeine (25 mg/kg given twice daily for 14 days) inhibited significantly both aggressivity and locomotion, and increased defensive-escape behaviour. Fifteen doses of CGS 21680 (0.1 mg/kg once a day) inhibited significantly both aggressivity and locomotion, too, without any other behavioural changes. Neither caffeine nor CGS21680 repeated treatment ending elicited withdrawal signs. Furthermore, CGS21680 repeated administration effects lasted still on the 4th day of withdrawal.