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@inproceedings{369613,
author = {Ševčíková, Sabina and Zahradníčková, Eva and Souček, Karel and Šmarda, Jan},
address = {Frederick, MD, USA},
booktitle = {The 17th annual meeting on oncogenes},
keywords = {Fos},
language = {eng},
location = {Frederick, MD, USA},
pages = {171-171},
publisher = {Foundation for Advanced Cancer Studies, Inc.},
title = {v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts},
year = {2001}
}
TY - JOUR
ID - 369613
AU - Ševčíková, Sabina - Zahradníčková, Eva - Souček, Karel - Šmarda, Jan
PY - 2001
TI - v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts
PB - Foundation for Advanced Cancer Studies, Inc.
CY - Frederick, MD, USA
KW - Fos
N2 - The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation.
ER -
ŠEVČÍKOVÁ, Sabina, Eva ZAHRADNÍČKOVÁ, Karel SOUČEK a Jan ŠMARDA. v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts. In \textit{The 17th annual meeting on oncogenes}. Frederick, MD, USA: Foundation for Advanced Cancer Studies, Inc., 2001, s.~171.
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