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@inproceedings{378300,
author = {Mohamed, Walid Fathalla and Pazdera, Pavel},
address = {Pardubice},
booktitle = {XXVth Conference of Organic Chemists},
edition = {1},
keywords = {Quinazolines; Thioureas; Guanidines; Desulfurization},
language = {eng},
location = {Pardubice},
isbn = {80-7194-349-5},
pages = {KS 8},
publisher = {Publishing House of Pardubice University},
title = {The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas},
year = {2001}
}
TY - JOUR
ID - 378300
AU - Mohamed, Walid Fathalla - Pazdera, Pavel
PY - 2001
TI - The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas
PB - Publishing House of Pardubice University
CY - Pardubice
SN - 8071943495
KW - Quinazolines
KW - Thioureas
KW - Guanidines
KW - Desulfurization
N2 - The model compound N3,N3-(3-oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene) thiourea 1 was synthesized in a one-pot reaction from N1-(2-cyanophenyl) benzamide as reported. It was proved from the computational studies of 1 that the competing nucleophile sites would be the N3 of quinazoline skeleton and sulfur atom. It was found that the 1 undergoes transamination reactions with primary and secondary amines. The compound 1 gives the alkylation reaction at the sulfur atom. The later result was attributed to the hard-soft theory. The model compound 1 reacts with secondary amines in the presence of H2O2 to produce the guanidine derivative by the elimination of the sulfanyl group.
ER -
MOHAMED, Walid Fathalla a Pavel PAZDERA. The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas. In \textit{XXVth Conference of Organic Chemists}. 1. vyd. Pardubice: Publishing House of Pardubice University, 2001, s.~KS 8, 2 s. ISBN~80-7194-349-5.
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