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@inproceedings{378300, author = {Mohamed, Walid Fathalla and Pazdera, Pavel}, address = {Pardubice}, booktitle = {XXVth Conference of Organic Chemists}, edition = {1}, keywords = {Quinazolines; Thioureas; Guanidines; Desulfurization}, language = {eng}, location = {Pardubice}, isbn = {80-7194-349-5}, pages = {KS 8}, publisher = {Publishing House of Pardubice University}, title = {The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas}, year = {2001} }
TY - JOUR ID - 378300 AU - Mohamed, Walid Fathalla - Pazdera, Pavel PY - 2001 TI - The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas PB - Publishing House of Pardubice University CY - Pardubice SN - 8071943495 KW - Quinazolines KW - Thioureas KW - Guanidines KW - Desulfurization N2 - The model compound N3,N3-(3-oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene) thiourea 1 was synthesized in a one-pot reaction from N1-(2-cyanophenyl) benzamide as reported. It was proved from the computational studies of 1 that the competing nucleophile sites would be the N3 of quinazoline skeleton and sulfur atom. It was found that the 1 undergoes transamination reactions with primary and secondary amines. The compound 1 gives the alkylation reaction at the sulfur atom. The later result was attributed to the hard-soft theory. The model compound 1 reacts with secondary amines in the presence of H2O2 to produce the guanidine derivative by the elimination of the sulfanyl group. ER -
MOHAMED, Walid Fathalla a Pavel PAZDERA. The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas. In \textit{XXVth Conference of Organic Chemists}. 1. vyd. Pardubice: Publishing House of Pardubice University, 2001, s.~KS 8, 2 s. ISBN~80-7194-349-5.
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