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@article{382091,
author = {Maloň, M. and Trávníček, Z. and Maryško, M. and Zbořil, R. and Mašláň, M. and Marek, Jaromír and Doležal, K. and Rolčík, J. and Kryštof, V. and Strnad, M.},
article_location = {Oxford, UK},
article_number = {1-2},
keywords = {ron(III) and copper(II) complexes; 6-benzylaminopurine derivatives; cytotoxic activity; CDK inhibitor; magnetic properties; crystal structures},
language = {eng},
issn = {0020-1693},
journal = {Inorganica Chimica Acta},
title = {Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N-6-benzylaminopurine derivatives},
volume = {323},
year = {2001}
}
TY - JOUR
ID - 382091
AU - Maloň, M. - Trávníček, Z. - Maryško, M. - Zbořil, R. - Mašláň, M. - Marek, Jaromír - Doležal, K. - Rolčík, J. - Kryštof, V. - Strnad, M.
PY - 2001
TI - Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N-6-benzylaminopurine derivatives
JF - Inorganica Chimica Acta
VL - 323
IS - 1-2
SP - 119
EP - 119
PB - Elsevier Science
SN - 00201693
KW - ron(III) and copper(II) complexes
KW - 6-benzylaminopurine derivatives
KW - cytotoxic activity
KW - CDK inhibitor
KW - magnetic properties
KW - crystal structures
N2 - Iron(III) complexes with 2-(3-hydroxypropylamino)-6-benzylaniino-9-isopropylpurine (Bohemin, HL1), in its protonized form, of the composition (H+HL1)(2)[FeCl5]. 2H(2)O (1), (H+HL1)(2)[FeCl5]. 3H(2)O (2) have been prepared by two different routes. A new way for synthesis of copper(II) complex with 6-(2-chlorobenzylamino)purine (HL2), [Cu-2(mu -Cl)(2)(mu -HL2)(2)(HL2)(2)Cl-2]. 2H(2)O (3), together with the preparation of copper(II) complex with 6-(3-chlorobenzylamino)purine (HL3), [Cu-2(mu -Cl)(2)(mu -HL3)(2)Cl-2] (4), is also reported. The characterization have been based on elemental analysis, electronic, infrared, ES + mass and Fe-57 Mossbauer spectra, conductivity data and magnetic susceptibility temperature measurements over the 4.5-300 K for 1-3, and 35-300 K for 4. temperature range, respectively. Molecular structure of an electroneutral form of the HL2 ligand, (HL2. 2H(2)O), and a protonized form of the HL3 ligand, (H+HL3-Cl), have been determined by a single-crystal X-ray analysis. A mononuclear trigonal-bipyramidal (for 1 and 2), binuclear octahedral (for 3) and binuclear trigonal-bipyramidal (for 4) structures of the complexes were proposed mainly on the basis of spectral and magnetic properties. An S = 3/2-5/2 spin-admixed state in 1 and 2 was found to be related to the presence of [FeCl5](2-) (S = 3/2) and [FeCl5(H2O)](2-) (S = 5/2) complex anions in I and 2, as found by Fe-57 Mossbauer spectroscopy. Cytotoxic activity of the complexes was determined by a calcein AM assay and IC50 values were also estimated. For testing, human malignant melanoma cell line G-361. human osteogenic sarcoma cell line HOS, human chronic myelogenous leukaemia K-562 and human breast adenocarcinoma cell line MCF7 were used. The inhibition of p34(cdc2) kinase by the complexes I and 2, which is known to be one of the important mechanisms responsible for cytotoxicity of cytokinin-derived compounds, was also studied.
ER -
MALOŇ, M., Z. TRÁVNÍČEK, M. MARYŠKO, R. ZBOŘIL, M. MAŠLÁŇ, Jaromír MAREK, K. DOLEŽAL, J. ROLČÍK, V. KRYŠTOF a M. STRNAD. Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N-6-benzylaminopurine derivatives. \textit{Inorganica Chimica Acta}. Oxford, UK: Elsevier Science, 2001, roč.~323, 1-2, s.~119-129. ISSN~0020-1693.
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