2001
Plectin repeats and modules: strategic cysteines and their presumed impact on cytolinker
JANDA, Lubomír; Jiří DAMBORSKÝ; Gerhard A. REZNICZEK a Gerhard WICHEZákladní údaje
Originální název
Plectin repeats and modules: strategic cysteines and their presumed impact on cytolinker
Autoři
JANDA, Lubomír; Jiří DAMBORSKÝ; Gerhard A. REZNICZEK a Gerhard WICHE
Vydání
Bioessays, 2001
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10600 1.6 Biological sciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14310/01:00005021
Organizační jednotka
Přírodovědecká fakulta
Změněno: 13. 2. 2002 06:03, prof. Mgr. Jiří Damborský, Dr.
Anotace
V originále
Plectin, a member of the cytolinkers protein family, plays a crucial role in cells as a stabilizing element of cells against mechanical stress. Its absence results in muscular dystrophy, skin blistering, and signs of neuropathy. The C-terminus domain of plectin contains several highly homologous repeat domains that also occur in other cytolinkers. Secondary structure analysis revealed that the building block of these domains, the PLEC repeat, is similar to the ankyrin repeat. We present a model, which comprises ~1900 amino acid, could be stabilized to maintain its structural integrity even udenr extensive mechanical stress. In this model, larger solenoid modules formed from PLEC repeats can be disulphide-bridged via conserved cysteines. Our hypothesis suggests that this process could be mediated by cytoplasmic NOS-generated products, such as the radical peroxynitrite. Reinforcement of molecular structure would provide a rationale why during exercising or physiological stress radicals are formed without necessarily being deleterious.
Návaznosti
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