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@inproceedings{383829,
author = {Pásek, Michal and Šimurda, Jiří},
address = {Pula (Croatia)},
booktitle = {Proceedings of the International Federation for Medical and Biologocal Engineering},
keywords = {cardiac cell; propafenone; quantitative modelling},
language = {eng},
location = {Pula (Croatia)},
isbn = {953-184-024-5},
pages = {1028-1031},
publisher = {Faculty of Electrical Engineering, Zagreb},
title = {Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells.},
year = {2001}
}
TY - JOUR
ID - 383829
AU - Pásek, Michal - Šimurda, Jiří
PY - 2001
TI - Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells.
PB - Faculty of Electrical Engineering, Zagreb
CY - Pula (Croatia)
SN - 9531840245
KW - cardiac cell
KW - propafenone
KW - quantitative modelling
N2 - A mathematical model of the interaction of propafenone with sodium channels is based on experimental data that demonstrate use dependent effect of the drug. Transitions among channel states are described by a kinetic diagram and a corre-sponding set of differential equations. The values of rate constants of the drug-receptor reaction are fitted to experimental data by repeated computer simulations using a genetic algorithm. The model suggests the following interpretation of the obtained experimental results: 1) The affinity of the drug to its binding site is high in the open and inactivated states while it is low in the resting state. 2) The biphasic development of the block during depolarization is consistent with a high association rate constant in the open state and a lower one in the inactivated state. 3) The observed double exponential time course of recovery of INa at resting voltage after depolarizing pulse may result from concurrent drug release from inactivated and non-inactivated blocked channels.
ER -
PÁSEK, Michal a Jiří ŠIMURDA. Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. In \textit{Proceedings of the International Federation for Medical and Biologocal Engineering}. Pula (Croatia): Faculty of Electrical Engineering, Zagreb, 2001, s.~1028-1031. ISBN~953-184-024-5.
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