2001
The Synthesis of New N3-Aryl-N1-(2-phenylquinazolin-4-yl)thioureas
MOHAMED, Walid Fathalla a Pavel PAZDERAZákladní údaje
Originální název
The Synthesis of New N3-Aryl-N1-(2-phenylquinazolin-4-yl)thioureas
Autoři
MOHAMED, Walid Fathalla a Pavel PAZDERA
Vydání
1. vyd. Pardubice, XXVth Conference of Organic Chemists, od s. KS 8, 2 s. 2001
Nakladatel
Publishing House of Pardubice University
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
10401 Organic chemistry
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14310/01:00005231
Organizační jednotka
Přírodovědecká fakulta
ISBN
80-7194-349-5
Klíčová slova anglicky
Quinazolines; Thioureas; Benzimidoyl isothiocyanates
Změněno: 8. 1. 2002 16:32, doc. RNDr. Pavel Pazdera, CSc.
Anotace
V originále
The reactions of N2-1-(2-cyanophenyl)-N1-thioxomethylidenebenzene-1-carboximidamide with amines and anilines afforded N3,N3-di R-N1-(2-phenyl-3,4-dihydroquinazolin-4-yliden)thiourea and N3-R-N1-(2-phenyl-quinazolin-4-yl)thiourea. This reaction was applied to involve more anilines with large substituents in order to examine the effect of these large substituents on the reaction pathway and to obtain large number of quinazolines with a big variety of substituents for biological activity screening. This process took place in a one pot reaction starting from the easily available benzamide derivative, which subsequently converted to the imidoyl chloride by the reaction with PCl5 , then to the isothiocyanate. The additon reaction of the isothiocyanate with anilines undergoes a series of spontaneous step of reactions, which finally ends by the formation of the quinazoline derivative.
Návaznosti
| GA203/01/1333, projekt VaV |
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| MSM 143100011, záměr |
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