| BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ a Jiří VÁCHA. Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population. Allergy. Denmark: Munksgaard International Publishers, 2002, roč. 57, č. 5, s. 447-449. ISSN 0105-4538. |
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@article{390214,
author = {Bučková, Dana and Izakovičová Hollá, Lydie and Vácha, Jiří},
article_location = {Denmark},
article_number = {5},
keywords = {allergic diseases; asthma; polymorphism; gene; PAI-1},
language = {eng},
issn = {0105-4538},
journal = {Allergy},
title = {Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population},
volume = {57},
year = {2002}
}
TY - JOUR
ID - 390214
AU - Bučková, Dana - Izakovičová Hollá, Lydie - Vácha, Jiří
PY - 2002
TI - Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population
JF - Allergy
VL - 57
IS - 5
SP - 447
EP - 447
PB - Munksgaard International Publishers
SN - 01054538
KW - allergic diseases
KW - asthma
KW - polymorphism
KW - gene
KW - PAI-1
N2 - Plasminogen activator inhibitor type 1 (PAI-1) is a glycoprotein that belongs to the serine protease inhibitor superfamily and has an essential role in tissue remodeling after inflammation. Recently, a single base pair deletion/insertion (4G/5G) polymorphism of the PAI-1 gene has been associated with an increased risk of asthma in nuclear families from the United Kingdom. Our findings support the idea that the 4G allele of the 4G/5G polymorphism in the PAI-1 gene may be a risk factor for IgE-mediated asthma and allergic diseases also in our Czech population.
ER -
BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ a Jiří VÁCHA. Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population. \textit{Allergy}. Denmark: Munksgaard International Publishers, 2002, roč.~57, č.~5, s.~447-449. ISSN~0105-4538.
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