BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ and Jiří VÁCHA. Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population. Allergy. Denmark: Munksgaard International Publishers, 2002, vol. 57, No 5, p. 447-449. ISSN 0105-4538.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population
Authors BUČKOVÁ, Dana (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Allergy, Denmark, Munksgaard International Publishers, 2002, 0105-4538.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Denmark
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.666
RIV identification code RIV/00216224:14110/02:00005377
Organization unit Faculty of Medicine
UT WoS 000175424400013
Keywords in English allergic diseases; asthma; polymorphism; gene; PAI-1
Tags allergic diseases, asthma, gene, PAI-1, polymorphism
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 12:41.
Abstract
Plasminogen activator inhibitor type 1 (PAI-1) is a glycoprotein that belongs to the serine protease inhibitor superfamily and has an essential role in tissue remodeling after inflammation. Recently, a single base pair deletion/insertion (4G/5G) polymorphism of the PAI-1 gene has been associated with an increased risk of asthma in nuclear families from the United Kingdom. Our findings support the idea that the 4G allele of the 4G/5G polymorphism in the PAI-1 gene may be a risk factor for IgE-mediated asthma and allergic diseases also in our Czech population.
Links
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
PrintDisplayed: 30/4/2024 10:16