J 2001

Effect of retinoic acid on the actin cytoskeleton in HL-60 cells

ZITTERBART, Karel and Renata VESELSKÁ

Basic information

Original name

Effect of retinoic acid on the actin cytoskeleton in HL-60 cells

Authors

ZITTERBART, Karel (203 Czech Republic, guarantor) and Renata VESELSKÁ (203 Czech Republic)

Edition

Neoplasma, Bratislava, Slovak Academic Press, 2001, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.637

RIV identification code

RIV/00216224:14110/01:00005470

Organization unit

Faculty of Medicine

UT WoS

000173672300006

Keywords in English

Apoptosis; cytoskeleton; F-actin; all-trans retinoic acid; differentiation; HL-60 cells

Tags

Tags

International impact, Reviewed
Změněno: 11/4/2010 23:37, MUDr. Karel Zitterbart, Ph.D.

Abstract

V originále

The morphological changes in actin cytoskeleton, taking place during apoptosis in cells of the human leukemic HL-60 cell line, were described. It is concluded that the actin cytoskeleton is a dynamic structure actively involved in the executive phase of the process of apoptosis. It is suggested that the rearrangement of the microfilament network and its subsequent degradation are necessary for the main morphological changes of apoptotic cells, i.e., plasma membrane blebbing and apoptotic bodies formation.

Links

GA304/00/0403, research and development project
Name: Změny cytoskeletu buněk nádorových linií v průběhu indukované apoptózy v závislosti na stádiu diferenciace.
Investor: Czech Science Foundation, Changes of the cytoskeleton in tumour cell lines during induced apoptosis in relation to different stages of differentiation