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@article{393931,
author = {Reichová, Naďa and Pazourek, Jiří and Polášková, Pavla and Havel, Josef},
article_location = {Weinheim},
article_number = {2},
keywords = {Capillary zone electrophoresis; Indirect detection; Memantine; Rimantadine},
language = {eng},
issn = {0173-0835},
journal = {Electrophoresis},
title = {Electrophoretic behavior of adamantane derivatives possessing antiviral activity and their determination by capillary zone electrophoresis with indirect detection},
volume = {23},
year = {2002}
}
TY - JOUR
ID - 393931
AU - Reichová, Naďa - Pazourek, Jiří - Polášková, Pavla - Havel, Josef
PY - 2002
TI - Electrophoretic behavior of adamantane derivatives possessing antiviral activity and their determination by capillary zone electrophoresis with indirect detection
JF - Electrophoresis
VL - 23
IS - 2
SP - 259
EP - 259
PB - WILEY-VCH Verlag GmbH
SN - 01730835
KW - Capillary zone electrophoresis
KW - Indirect detection
KW - Memantine
KW - Rimantadine
N2 - Separation and determination of adamantane derivatives with antiviral activity, namely amantadine (1-adamantan amine), memantine (1-amino-3,5-dimethyl adamantane) and rimantadine (alpha-methyl-1-adamantane methylamine), were examined by capillary zone electrophoresis. After optimisation, indirect detection method using 5 mM 4-methylbenzylamine in ethanol/water solution (1:4) as simultaneously absorbing and buffering background electrolyte with detection at 210 nm was found suitable for determination of the individual compounds (limit of detection was 0.35 mg/l for memantine hydrochloride, S/N=3). Baseline separation of all the three compounds was reached by addition of alpha- or beta-cyclodextrins to the electrolyte in concentration of 20 and 2 mM, respectively.
ER -
REICHOVÁ, Naďa, Jiří PAZOUREK, Pavla POLÁŠKOVÁ a Josef HAVEL. Electrophoretic behavior of adamantane derivatives possessing antiviral activity and their determination by capillary zone electrophoresis with indirect detection. \textit{Electrophoresis}. Weinheim: WILEY-VCH Verlag GmbH, 2002, roč.~23, č.~2, s.~259-262. ISSN~0173-0835.
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