The relationship among apolipoprotein(a) polymorphisms, the
low-density lipoprotein receptor-related protein, and the very
low density lipoprotein receptor genes, and plasma
lipoprotein(A) concentration in the Czech population

J 2002

The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population

BENEŠ, Petr; Jan MUŽÍK; Jaroslav BENEDÍK; Vladimír ZNOJIL; Jiří VÁCHA et al.

Základní údaje

Originální název

The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population

Autoři

BENEŠ, Petr; Jan MUŽÍK; Jaroslav BENEDÍK; Vladimír ZNOJIL a Jiří VÁCHA

Vydání

Human Biology, Detroit, Wayne State University Press, 2002, 0018-7143

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.242

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/02:00005745

Organizační jednotka

Lékařská fakulta

UT WoS

000174933700009

Klíčová slova anglicky

apolipoprotein(a); lipoprotein(a); low density lipoprotein receptor-related protein; very low density lipoprotein receptor; genetic polymorphism

Štítky

apolipoprotein(a), genetic polymorphism, lipoprotein(a)

Změněno: 8. 4. 2003 11:59, prof. MUDr. Jiří Vácha, DrSc.

Anotace

V originále

Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery disease (CAD), which is strongly genetically determined. This study was designed to investigate the relationship between the K-IV and (TTTTA)(n) apolipoprotein(a) [apo(a), protein; APOA, gene] polymorphisms, as well as the C766T low-density lipoprotein receptor-related protein (LRP) and the (CGG)(n) very low density lipoprotein receptor (VLDLR) polymorphisms on the one hand, and plasma Lp(a) levels in Czech subjects who underwent coronary angiography on the other hand. The lengths of the alleles of the APOA K-IV and (TTTTA), polymorphisms were strongly inversely correlated with plasma Lp(a) levels in univariate analysis (r = -0.41, p < 10(-4) and r = -0.20, p < 0.01, respectively). Multivariate analysis revealed significant associations between the APOA polymorphisms studied and plasma Lp(a) levels in subjects expressing only one APOA K-IV allele (p < 10(-6) for K-IV and p < 0.001 for TTTTA). In subjects expressing both APOA K-IV alleles, the multivariate analysis revealed that only the APOA K-IV alleles were inversely correlated with plasma Lp(a) levels (p < 0.001). Associations between both the LRP and VLDLR gene polymorphisms and plasma Lp(a) levels were only of borderline significance (p < 0.06 and p < 0.07, respectively) and were not confirmed in multivariate analysis. In conclusion, both APOA length polymorphisms significantly influenced plasma Lp(a) concentration in the Czech population studied, and this circumstance could explain the association in this population observed earlier between APOA (TTTTA)(n) polymorphism and CAD (Benes et al. 2000). Only a minor role in the regulation of plasma Lp(a) levels is suggested for the C766T LRP and the (CGG)(n) VLDLR polymorphisms.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BENEŠ, Petr; Jan MUŽÍK; Jaroslav BENEDÍK; Vladimír ZNOJIL a Jiří VÁCHA. The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. Human Biology. Detroit: Wayne State University Press, 2002, roč. 74, č. 1, s. 129-136. ISSN 0018-7143.

@article{403605,
   author = {Beneš, Petr and Mužík, Jan and Benedík, Jaroslav and Znojil, Vladimír and Vácha, Jiří},
   article_location = {Detroit},
   article_number = {1},
   keywords = {apolipoprotein(a); lipoprotein(a); low density lipoprotein receptor-related protein; very low density lipoprotein receptor; genetic polymorphism},
   language = {eng},
   issn = {0018-7143},
   journal = {Human Biology},
   title = {The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population},
   volume = {74},
   year = {2002}
}

TY  - JOUR
ID  - 403605
AU  - Beneš, Petr - Mužík, Jan - Benedík, Jaroslav - Znojil, Vladimír - Vácha, Jiří
PY  - 2002
TI  - The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population
JF  - Human Biology
VL  - 74
IS  - 1
SP  - 129
EP  - 129
PB  - Wayne State University Press
SN  - 00187143
KW  - apolipoprotein(a)
KW  - lipoprotein(a)
KW  - low density lipoprotein receptor-related protein
KW  - very low density lipoprotein receptor
KW  - genetic polymorphism
N2  - Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery disease (CAD), which is strongly genetically determined. This study was designed to investigate the relationship between the K-IV and (TTTTA)(n) apolipoprotein(a) [apo(a), protein; APOA, gene] polymorphisms, as well as the C766T low-density lipoprotein receptor-related protein (LRP) and the (CGG)(n) very low density lipoprotein receptor (VLDLR) polymorphisms on the one hand, and plasma Lp(a) levels in Czech subjects who underwent coronary angiography on the other hand. The lengths of the alleles of the APOA K-IV and (TTTTA), polymorphisms were strongly inversely correlated with plasma Lp(a) levels in univariate analysis (r = -0.41, p < 10(-4) and r = -0.20, p < 0.01, respectively). Multivariate analysis revealed significant associations between the APOA polymorphisms studied and plasma Lp(a) levels in subjects expressing only one APOA K-IV allele (p < 10(-6) for K-IV and p < 0.001 for TTTTA). In subjects expressing both APOA K-IV alleles, the multivariate analysis revealed that only the APOA K-IV alleles were inversely correlated with plasma Lp(a) levels (p < 0.001). Associations between both the LRP and VLDLR gene polymorphisms and plasma Lp(a) levels were only of borderline significance (p < 0.06 and p < 0.07, respectively) and were not confirmed in multivariate analysis. In conclusion, both APOA length polymorphisms significantly influenced plasma Lp(a) concentration in the Czech population studied, and this circumstance could explain the association in this population observed earlier between APOA (TTTTA)(n) polymorphism and CAD (Benes et al. 2000). Only a minor role in the regulation of plasma Lp(a) levels is suggested for the C766T LRP and the (CGG)(n) VLDLR polymorphisms.
ER  -

BENEŠ, Petr; Jan MUŽÍK; Jaroslav BENEDÍK; Vladimír ZNOJIL a Jiří VÁCHA. The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. \textit{Human Biology}. Detroit: Wayne State University Press, 2002, roč.~74, č.~1, s.~129-136. ISSN~0018-7143.

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