Involvement of 5-HT1A and  5-HT1B Receptors in Modulation of
Methamphetamine I.V. Self-Administration in Rats

D 2002

Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats

ŠULCOVÁ, Alexandra, Jana NOVÁKOVÁ a Jana VINKLEROVÁ

Základní údaje

Originální název

Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats

Autoři

ŠULCOVÁ, Alexandra (203 Česká republika, garant), Jana NOVÁKOVÁ (203 Česká republika) a Jana VINKLEROVÁ (203 Česká republika)

Vydání

Quebec, Canada, The 7th NIDA International Forum, s. 43-43, 2002

Nakladatel

US National Institute on Drug Addiction (NIDA)

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Kanada

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/02:00006178

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

methamphetamine; self-administration; 5-HT1A receptor; 5-HT1B receptor; rats

Štítky

5-HT1A receptor, 5-HT1B receptor, methamphetamine, rats, self-administration

Změněno: 13. 5. 2003 16:40, prof. MUDr. Alexandra Šulcová, CSc.

Anotace

V originále

Methamphetamine acts neurotoxically in the brain, also on the serotonergic system, what is believed to endorse its behavioral effects and abuse. Thus, the present study ascertained the effects of 5-HT1A and 5-HT1B receptor ligands on intake of methamphetamine in rats with dependence raised in i. v. self-administration procedure (a fixed-ratio schedule: FR). Rats with stable methamphetamine intake on FR3 were acutely pretreated with serotonergics 15 minutes prior to self-administration session. The intraperitoneal pretreatment used: a) saline solution as a control (2.0 ml/kg, n=6), b) 5-HT1A/B agonist RU24969 (0.5; 1.5 and 4.5 mg/kg, n=13), c) 5-HT1A agonist 8-OH-DPAT (0.3; 1.0 and 3.0 mg/kg, n=6, d) 5-HT1B agonist CGS 12066B (1.0; 5.0 and 15.0 mg/kg, n=10). Statistical analysis was performed by the Wilcoxon matched-pairs signed-ranks test, two-tailed. Agonist of 5-HT1A receptor subtype had no significant influence on methamphetamine intake. The drug intake was partially suppressed by mixed 5-HT1A/B agonist RU24969 and significantly inhibited after the pretreatment with 5-HT1B agonist CGS 12066B. According to the present results the 5-HT1B receptor plasticity seems to play important role for the conditioned reward responding to methamphetamine i. v. self-administration while the 5-HT1A receptor subtype is not involved. These findings correspond well with analogous experience of Fletcher and Korth (Behav Pharmacol, 1999, 10, 183-193) received while testing effects of some other serotonergic ligands on d-amphetamine i.v. self-administration.

Citovat

ŠULCOVÁ, Alexandra, Jana NOVÁKOVÁ a Jana VINKLEROVÁ. Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats. In The 7th NIDA International Forum. Quebec, Canada: US National Institute on Drug Addiction (NIDA), 2002, s. 43.

@inproceedings{404331,
   author = {Šulcová, Alexandra and Nováková, Jana and Vinklerová, Jana},
   address = {Quebec, Canada},
   booktitle = {The 7th NIDA International Forum},
   keywords = {methamphetamine; self-administration; 5-HT1A receptor; 5-HT1B receptor; rats},
   language = {eng},
   location = {Quebec, Canada},
   pages = {43-43},
   publisher = {US National Institute on Drug Addiction (NIDA)},
   title = {Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats},
   year = {2002}
}

TY  - JOUR
ID  - 404331
AU  - Šulcová, Alexandra - Nováková, Jana - Vinklerová, Jana
PY  - 2002
TI  - Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats
PB  - US National Institute on Drug Addiction (NIDA)
CY  - Quebec, Canada
KW  - methamphetamine
KW  - self-administration
KW  - 5-HT1A receptor
KW  - 5-HT1B receptor
KW  - rats
N2  - Methamphetamine acts neurotoxically in the brain, also on the serotonergic system, what is believed to endorse its behavioral effects and abuse. Thus, the present study ascertained the effects of 5-HT1A and 5-HT1B receptor ligands on intake of methamphetamine in rats with dependence raised in i. v. self-administration procedure (a fixed-ratio schedule: FR). Rats with stable methamphetamine intake on FR3 were acutely pretreated with serotonergics 15 minutes prior to self-administration session. The intraperitoneal pretreatment used: a) saline solution as a control (2.0 ml/kg, n=6), b) 5-HT1A/B agonist RU24969 (0.5; 1.5 and 4.5 mg/kg, n=13), c) 5-HT1A agonist 8-OH-DPAT (0.3; 1.0 and 3.0 mg/kg, n=6, d) 5-HT1B agonist CGS 12066B (1.0; 5.0 and 15.0 mg/kg, n=10). Statistical analysis was performed by the Wilcoxon matched-pairs signed-ranks test, two-tailed. Agonist of 5-HT1A receptor subtype had no significant influence on methamphetamine intake. The drug intake was partially suppressed by mixed 5-HT1A/B agonist RU24969 and significantly inhibited after the pretreatment with 5-HT1B agonist CGS 12066B. According to the present results the 5-HT1B receptor plasticity seems to play important role for the conditioned reward responding to methamphetamine i. v. self-administration while the 5-HT1A receptor subtype is not involved. These findings correspond well with analogous experience of Fletcher and Korth (Behav Pharmacol, 1999, 10, 183-193) received while testing effects of some other serotonergic ligands on d-amphetamine i.v. self-administration.
ER  -

ŠULCOVÁ, Alexandra, Jana NOVÁKOVÁ a Jana VINKLEROVÁ. Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats. In \textit{The 7th NIDA International Forum}. Quebec, Canada: US National Institute on Drug Addiction (NIDA), 2002, s.~43.

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