Synthesis, characterization and antitumour activity of
copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray
structure of 6-(4-chloro-benzylamino)purinium perchlorate.

J 2002

Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.

MALOŇ, M.; Z. TRÁVNÍČEK; M. MARYŠKO; Jaromír MAREK; K. DOLEŽAL et al.

Základní údaje

Originální název

Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.

Autoři

MALOŇ, M.; Z. TRÁVNÍČEK; M. MARYŠKO; Jaromír MAREK ; K. DOLEŽAL; J. ROLČÍK a M. STRNAD

Vydání

Transition Metal Chemistry, Dordrecht, Kluwer Academic Publishers, 2002, 0340-4285

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.949

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/02:00006358

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

BIOLOGICAL ACTIVITY; 6-(2-CHLOROBENZYLAMINO)PURINE

Štítky

6-(2-CHLOROBENZYLAMINO)PURINE, BIOLOGICAL ACTIVITY

Změněno: 21. 5. 2003 10:36, doc. RNDr. Jaromír Marek, Ph.D.

Anotace

V originále

Copper(II) complexes with 6-(4-chlorobenzylamino)purine (HL) have been prepared and characterized by elemental analysis, electronic, i.r., ES + mass and C-13-n.m.r. spectra, and by magnetic and conductivity data. Based on these physical methods, mainly the temperature dependence of magnetic susceptibility data, we conclude that the complexes are: [Cu-2(mu-Cl)(2)(mu-HL)(2)Cl-2] (1) and [CuCl3(H+L)(2)]Cl (2). They have been studied for their possible antitumour activity against human malignant melanoma G-361, human osteogenic sarcoma HOS, human chronic myelogenous leukaemia K-562 and human breast adenocarcinoma MCF7 cells in vitro. The IC50 values were determined by calcein AM assay. The molecular structure of 6-(4-chlorobenzylamino)purinium perchlorate, i.e. a protonated form of the free HL ligand, has been determined by a single crystal X-ray analysis.

Návaznosti

GA203/00/0152, projekt VaV

Název: Syntéza, studium a biologická aktivita komplexních sloučenin vybraných přechodných kovů s purinovými deriváty

Citovat

MALOŇ, M.; Z. TRÁVNÍČEK; M. MARYŠKO; Jaromír MAREK; K. DOLEŽAL; J. ROLČÍK a M. STRNAD. Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate. Transition Metal Chemistry. Dordrecht: Kluwer Academic Publishers, 2002, roč. 27, č. 6, s. 580-586. ISSN 0340-4285.

@article{405100,
   author = {Maloň, M. and Trávníček, Z. and Maryško, M. and Marek, Jaromír and Doležal, K. and Rolčík, J. and Strnad, M.},
   article_location = {Dordrecht},
   article_number = {6},
   keywords = {BIOLOGICAL ACTIVITY; 6-(2-CHLOROBENZYLAMINO)PURINE},
   language = {eng},
   issn = {0340-4285},
   journal = {Transition Metal Chemistry},
   title = {Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.},
   volume = {27},
   year = {2002}
}

TY  - JOUR
ID  - 405100
AU  - Maloň, M. - Trávníček, Z. - Maryško, M. - Marek, Jaromír - Doležal, K. - Rolčík, J. - Strnad, M.
PY  - 2002
TI  - Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.
JF  - Transition Metal Chemistry
VL  - 27
IS  - 6
SP  - 580
EP  - 580
PB  - Kluwer Academic Publishers
SN  - 03404285
KW  - BIOLOGICAL ACTIVITY
KW  - 6-(2-CHLOROBENZYLAMINO)PURINE
N2  - Copper(II) complexes with 6-(4-chlorobenzylamino)purine (HL) have been prepared and characterized by elemental analysis, electronic, i.r., ES + mass and C-13-n.m.r. spectra, and by magnetic and conductivity data. Based on these physical methods, mainly the temperature dependence of magnetic susceptibility data, we conclude that the complexes are: [Cu-2(mu-Cl)(2)(mu-HL)(2)Cl-2] (1) and [CuCl3(H+L)(2)]Cl (2). They have been studied for their possible antitumour activity against human malignant melanoma G-361, human osteogenic sarcoma HOS, human chronic myelogenous leukaemia K-562 and human breast adenocarcinoma MCF7 cells in vitro. The IC50 values were determined by calcein AM assay. The molecular structure of 6-(4-chlorobenzylamino)purinium perchlorate, i.e. a protonated form of the free HL ligand, has been determined by a single crystal X-ray analysis.
ER  -

MALOŇ, M.; Z. TRÁVNÍČEK; M. MARYŠKO; Jaromír MAREK; K. DOLEŽAL; J. ROLČÍK a M. STRNAD. Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate. \textit{Transition Metal Chemistry}. Dordrecht: Kluwer Academic Publishers, 2002, roč.~27, č.~6, s.~580-586. ISSN~0340-4285.

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