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@article{405579,
author = {Vetvička, V. and Beneš, Petr and Fusek, M.},
article_location = {England},
article_number = {9},
keywords = {procathepsin D; cathepsin D; breast cancer; receptor},
language = {eng},
issn = {0929-1903},
journal = {Cancer Gene Therapy},
title = {Procathepsin D in breast cancer: What do we know? Effects of ribozymes and other inhibitors},
volume = {2002},
year = {2002}
}
TY - JOUR
ID - 405579
AU - Vetvička, V. - Beneš, Petr - Fusek, M.
PY - 2002
TI - Procathepsin D in breast cancer: What do we know? Effects of ribozymes and other inhibitors
JF - Cancer Gene Therapy
VL - 2002
IS - 9
SP - 854
EP - 854
PB - Nature Publishing Group
SN - 09291903
KW - procathepsin D
KW - cathepsin D
KW - breast cancer
KW - receptor
N2 - Procathepsin D (pCD) is a major secreted glycoprotein in some human breast and other cancer cell lines. Several groups proposed that pCD served as a growth factor for these cell lines. Secreted pCD has been demonstrated in tissue section, tissue culture supernatants, carcinoma cytosols, and nipple aspirates. Moreover, several clinical studies suggested a potential role for this molecule in metastasis because its concentration in primary tumors correlated with an increased incidence of tumor metastases. In this paper, the effects of pCD were evaluated by proliferation in vitro and by mouse studies in vivo. Subsequent flow cytometry experiments showed the specificity of pCD binding to cancer cells. Cell cultivation showed that addition of either pCD or its activation peptide stimulates growth of cancer cells. These effects can be inhibited both in vitro and in vivo by anti-pCD antibodies. In addition, production of pCD can be inhibited by specifically designed ribozymes. This paper is focused on mitogenic effects of pCD, which seem to involve interaction of the activation peptide with as yet unidentified receptor. Different mechanisms by which pCD could promote development and spread of cancer cells are discussed.
ER -
VETVIČKA, V., Petr BENEŠ and M. FUSEK. Procathepsin D in breast cancer: What do we know? Effects of ribozymes and other inhibitors. \textit{Cancer Gene Therapy}. England: Nature Publishing Group, 2002, vol.~2002, No~9, p.~854-863. ISSN~0929-1903.
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