Reduced Nephrotoxicity od Conventional Amphotericin B Therapy
after Minimal Nephroprotective Measures: Animal Experiments and
Clinical Study.

J 2002

Reduced Nephrotoxicity od Conventional Amphotericin B Therapy after Minimal Nephroprotective Measures: Animal Experiments and Clinical Study.

MAYER, Jiří, Michael DOUBEK, J. DOUBEK a Drahomír HORKÝ

Základní údaje

Originální název

Reduced Nephrotoxicity od Conventional Amphotericin B Therapy after Minimal Nephroprotective Measures: Animal Experiments and Clinical Study.

Autoři

MAYER, Jiří (203 Česká republika, garant), Michael DOUBEK (203 Česká republika), J. DOUBEK (203 Česká republika) a Drahomír HORKÝ (203 Česká republika)

Vydání

The Journal of Infectious Diseases, Chicago - USA, 2002, 0022-1899

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.857

Kód RIV

RIV/00216224:14330/02:00006586

Organizační jednotka

Fakulta informatiky

Klíčová slova anglicky

amphotericin B deoxycholate - nephrotoxicity - rats

Změněno: 31. 5. 2003 10:27, RNDr. JUDr. Vladimír Šmíd, CSc.

Anotace

V originále

Amphotericin B (AmB)-treated rats develop severe polyuria, polydypsia, impairment of renal concentrating ability, and morphologic signs of tubular damage. However, renal insufficiency develops quickly only in animals in which water intake is restricted to the median volume drunk by rats of the control group. Therefore, vigorous hydration seems crucial for prevention of AmB-induced nephrotoxicity. In a clinical study, 61 patients with hematologic malignancies receiving AmB therapy were massively hydrated to ensure urine output of > or =4000 mL/day. Urine sodium, potassium, and magnesium were also measured, and all losses were supplemented (potassium as a 7.45% solution via central venous catheter). AmB-treated patients developed signs of renal tubular damage (increased fractional excretion of sodium and potassium) and required large amounts of ion supplementation. The serum ion concentration and creatinine clearance remained stable. No clinically significant renal damage developed to force premature cessation of AmB treatment.

Návaznosti

NL6514, projekt VaV

Název: Jednoduché nefroprotektivní postupy v profylaxi nefrotoxicity konvenčního amfotericinu B u onkologických pacientů

Investor: Ministerstvo zdravotnictví ČR, Jednoduché nefroprotektivní postupy v profylaxi nefrotoxicity konvenčního amfotericinu B u onkologických pacientů

Citovat

MAYER, Jiří, Michael DOUBEK, J. DOUBEK a Drahomír HORKÝ. Reduced Nephrotoxicity od Conventional Amphotericin B Therapy after Minimal Nephroprotective Measures: Animal Experiments and Clinical Study. The Journal of Infectious Diseases. Chicago - USA, 2002, roč. 186, č. 3, s. 379-388. ISSN 0022-1899.

@article{406178,
   author = {Mayer, Jiří and Doubek, Michael and Doubek, J. and Horký, Drahomír},
   article_location = {Chicago - USA},
   article_number = {3},
   keywords = {amphotericin B deoxycholate - nephrotoxicity - rats},
   language = {eng},
   issn = {0022-1899},
   journal = {The Journal of Infectious Diseases},
   title = {Reduced Nephrotoxicity od Conventional Amphotericin B Therapy after Minimal Nephroprotective Measures: Animal Experiments and Clinical Study.},
   volume = {186},
   year = {2002}
}

TY  - JOUR
ID  - 406178
AU  - Mayer, Jiří - Doubek, Michael - Doubek, J. - Horký, Drahomír
PY  - 2002
TI  - Reduced Nephrotoxicity od Conventional Amphotericin B Therapy after Minimal Nephroprotective Measures: Animal Experiments and Clinical Study.
JF  - The Journal of Infectious Diseases
VL  - 186
IS  - 3
SP  - 379-388
EP  - 379-388
SN  - 00221899
KW  - amphotericin B deoxycholate - nephrotoxicity - rats
N2  - Amphotericin B (AmB)-treated rats develop severe polyuria, polydypsia, impairment of renal concentrating ability, and morphologic signs of tubular damage. However, renal insufficiency develops quickly only in animals in which water intake is restricted to the median volume drunk by rats of the control group. Therefore, vigorous hydration seems crucial for prevention of AmB-induced nephrotoxicity. In a clinical study, 61 patients with hematologic malignancies receiving AmB therapy were massively hydrated to ensure urine output of > or =4000 mL/day. Urine sodium, potassium, and magnesium were also measured, and all losses were supplemented (potassium as a 7.45% solution via central venous catheter). AmB-treated patients developed signs of renal tubular damage (increased fractional excretion of sodium and potassium) and required large amounts of ion supplementation. The serum ion concentration and creatinine clearance remained stable. No clinically significant renal damage developed to force premature cessation of AmB treatment.
ER  -

MAYER, Jiří, Michael DOUBEK, J. DOUBEK a Drahomír HORKÝ. Reduced Nephrotoxicity od Conventional Amphotericin B Therapy after Minimal Nephroprotective Measures: Animal Experiments and Clinical Study. \textit{The Journal of Infectious Diseases}. Chicago - USA, 2002, roč.~186, č.~3, s.~379-388. ISSN~0022-1899.

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