2002
Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)
BERÁNEK, Michal, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Viera KUHROVÁ, Jiří VÁCHA et. al.Základní údaje
Originální název
Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)
Autoři
BERÁNEK, Michal (203 Česká republika, garant), Svatava TSCHÖPLOVÁ (203 Česká republika), Kateřina KAŇKOVÁ (203 Česká republika), Viera KUHROVÁ (203 Česká republika) a Jiří VÁCHA (203 Česká republika)
Vydání
Human Immunology, USA, ELSEVIER SCIENCE INC, 2002, 0198-8859
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
Genetika a molekulární biologie
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 2.573
Kód RIV
RIV/00216224:14110/02:00006679
Organizační jednotka
Lékařská fakulta
UT WoS
000181137600008
Klíčová slova anglicky
bFGF; genetic polymorphism; linkage disequilibrium
Změněno: 24. 6. 2009 15:25, prof. MUDr. Kateřina Kaňková, Ph.D.
Anotace
V originále
Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes. We investigated possible genetic polymorphism in the promoter and 5 flanking region of the bFGF gene. Polymorphism was analysed by means of heteroduplex analysis, fragments with altered mobility were sequenced. Three novel substitutions (-553T/A, -834T/A and -921C/G) were identified in the promoter region. Allele frequencies in a sample of healthy Caucasian subjects (n=126) were determined by polymerase chain reactions followed by restriction analyses with specific endonucleases. The frequencies of the mutated alleles (-553A, -834A and 921G) were 0.04, 0.05 and 0.14, respectively. Newly identified variants in the bFGF gene promoter appear to be common polymorphisms in the Czech population.
Návaznosti
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