Detailed Information on Publication Record
2002
5-methyl-cytosine as a marker for monitoring of DNA methylation
HAVLIŠ, Jan and Martin TRBUŠEKBasic information
Original name
5-methyl-cytosine as a marker for monitoring of DNA methylation
Authors
HAVLIŠ, Jan (203 Czech Republic, guarantor) and Martin TRBUŠEK (203 Czech Republic)
Edition
Journal of Chromatography B, Amsterdam, Elsevier, 2002, 1570-0232
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10406 Analytical chemistry
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.913
RIV identification code
RIV/00216224:14310/02:00006750
Organization unit
Faculty of Science
UT WoS
000179784700022
Keywords in English
5-methylcytosine; reviews; DNA
Tags
Tags
International impact, Reviewed
Změněno: 2/7/2009 18:59, doc. Mgr. Jan Havliš, Dr.
Abstract
V originále
The extent of the DNA methylation of genomic DNA as well as the methylation pattern of many gene-regulatory areas are important aspects with regard to the state of genetic information, especially their expression. There is growing evidence that aberrant methylation is associated with many serious pathological consequences. As genetic research advances, many different approaches have been employed to determine the overall level of DNA methylation in a genome or to reveal the methylation state of particular nucleotide residues, starting from semiquantitative methods up to new and powerful techniques. In this paper, the currently employed techniques are reviewed both from the point of view of their relevance in genomic research and of their analytical application. The methods discussed include approaches based on chromatographic separation, separation in an electric field, and some other methodological procedures.
Links
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