D 2002

Antiradical activity of aporhine alkaloids

PAULOVÁ, Hana; Hana BOCHOŘÁKOVÁ a Eva TÁBORSKÁ

Základní údaje

Originální název

Antiradical activity of aporhine alkaloids

Název anglicky

Antiradical activity of aporhine alkaloids

Autoři

PAULOVÁ, Hana; Hana BOCHOŘÁKOVÁ a Eva TÁBORSKÁ

Vydání

Bratislava, s. 260-260, 2002

Nakladatel

VEDA, vydavatelsstvoSAV

Další údaje

Typ výsledku

Stať ve sborníku

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

ISBN

nepřiděleno

Klíčová slova anglicky

aporphine alkaloids; antioxidative; DPPH; HPLC-EC

Štítky

Změněno: 9. 12. 2002 11:23, prof. RNDr. Eva Táborská, CSc.

Anotace

V originále

The aim of this work was to determine the antiradical ability using DPPH assay and the redox properties (oxidative potential) using HPLC-EC. Antiradical activity was related with a presence, number and position of phenolic groups. The presence of free electron pair on the nitrogen atom also participated in stronger antiradical activity, as was described for the inhibition of lipid peroxidation. The antiradical activity of corytuberine (IC50= 11,4 uM), the strongest antioxidant among the aporphines tested, was comparable with the activity of ascorbic acid (IC50= 10,3 uM). One mole of corytuberine reacted approximately with 2 moles of DPPH radical, similarly as ascorbic acid. Oxidative potentials characterising the ability of aporhines to be oxidised were in agreement with results obtained using DPPH. Aporphines glaucine, magnoflorine, menisperine, isocorydine, bulbocapnine, isothebaine, corydine with lower oxidative potential (<450mV) are a good scavengers of DPPH. These findings indicate that HPLC-EC method together with DPPH method is a good tool to evaluate the antiradical activity of compounds of natural origin.