Antiradical activity of aporhine alkaloids

PAULOVÁ, Hana, Hana BOCHOŘÁKOVÁ a Eva TÁBORSKÁ. Antiradical activity of aporhine alkaloids. Bratislava: VEDA, vydavatelsstvoSAV, 2002, s. 260. ISBN nepřiděleno.

Základní údaje

• Originální název: Antiradical activity of aporhine alkaloids
• Název anglicky: Antiradical activity of aporhine alkaloids
• Autoři: PAULOVÁ, Hana, Hana BOCHOŘÁKOVÁ a Eva TÁBORSKÁ.
• Vydání: Bratislava, s. 260-260, 2002.
• Nakladatel: VEDA, vydavatelsstvoSAV

Další údaje

• Typ výsledku: Stať ve sborníku
• Utajení: není předmětem státního či obchodního tajemství
• Organizační jednotka: Lékařská fakulta
• ISBN: nepřiděleno
• Klíčová slova anglicky: aporphine alkaloids; antioxidative; DPPH; HPLC-EC
• Štítky: antioxidative, Aporphine alkaloids, DPPH, HPLC-EC

Anotace

The aim of this work was to determine the antiradical ability using DPPH assay and the redox properties (oxidative potential) using HPLC-EC. Antiradical activity was related with a presence, number and position of phenolic groups. The presence of free electron pair on the nitrogen atom also participated in stronger antiradical activity, as was described for the inhibition of lipid peroxidation. The antiradical activity of corytuberine (IC50= 11,4 uM), the strongest antioxidant among the aporphines tested, was comparable with the activity of ascorbic acid (IC50= 10,3 uM). One mole of corytuberine reacted approximately with 2 moles of DPPH radical, similarly as ascorbic acid. Oxidative potentials characterising the ability of aporhines to be oxidised were in agreement with results obtained using DPPH. Aporphines glaucine, magnoflorine, menisperine, isocorydine, bulbocapnine, isothebaine, corydine with lower oxidative potential (<450mV) are a good scavengers of DPPH. These findings indicate that HPLC-EC method together with DPPH method is a good tool to evaluate the antiradical activity of compounds of natural origin.