NMR of Nucleic Acids

FIALA, Radovan and Vladimír SKLENÁŘ. NMR of Nucleic Acids. In ZERBE, Oliver. BioNMR in Drug Research. 1st ed. Weinheim: Wiley-VCH, 2002, p. 121-145. Methods and Principles in Medicinal Chemistry. ISBN 3-527-30465-7.

Basic information

• Original name: NMR of Nucleic Acids
• Authors: FIALA, Radovan (203 Czech Republic) and Vladimír SKLENÁŘ (203 Czech Republic, guarantor).
• Edition: 1. vyd. Weinheim, BioNMR in Drug Research, p. 121-145, Methods and Principles in Medicinal Chemistry, 2002.
• Publisher: Wiley-VCH

Other information

• Original language: English
• Type of outcome: Chapter(s) of a specialized book
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14310/02:00006909
• Organization unit: Faculty of Science
• ISBN: 3-527-30465-7
• Keywords in English: NMR; nuclear magnetic resonance; nucleic acid; DNA; RNA; structure; dynamics
• Tags: DNA, dynamics, NMR, nuclear magnetic resonance, nucleic acid, RNA, structure

Abstract

The paper concentrates primarily on the recent development of the high-resolution NMR techniques that have shown potential of increasing the range of promising applications and capability to provide new structural information. These include the 2H, 13C, and 15N isotope-labeling techniques for RNA and DNA, sensitivity optimized multi-dimensional NMR experiments, techniques to detect hydrogen-bond networks, applications of residual dipolar couplings for extracting structural restrains, and relaxation studies providing the information on dynamics and structure.

Links

• LN00A016, research and development project: Name: BIOMOLEKULÁRNÍ CENTRUM

Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular Center