DOSTÁLEK, Miroslav, Jiří SLÍVA, Eva HADAŠOVÁ a Josef TOMANDL. Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine. Bratislavské lekárské listy. Bratislava: Slovak Academic Press, s.r.o. Bratislava, 2002, roč. 103, č. 9, s. 310-310. ISSN 0006-9248. |
Další formáty:
BibTeX
LaTeX
RIS
@article{407324, author = {Dostálek, Miroslav and Slíva, Jiří and Hadašová, Eva and Tomandl, Josef}, article_location = {Bratislava}, article_number = {9}, keywords = {dextromethorphane; fluoxetine; methamphetamine}, language = {eng}, issn = {0006-9248}, journal = {Bratislavské lekárské listy}, title = {Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine}, url = {www.bmj.cz}, volume = {103}, year = {2002} }
TY - JOUR ID - 407324 AU - Dostálek, Miroslav - Slíva, Jiří - Hadašová, Eva - Tomandl, Josef PY - 2002 TI - Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine JF - Bratislavské lekárské listy VL - 103 IS - 9 SP - 310-310 EP - 310-310 PB - Slovak Academic Press, s.r.o. Bratislava SN - 00069248 KW - dextromethorphane KW - fluoxetine KW - methamphetamine UR - www.bmj.cz N2 - The purpose of this study was to assess pharmacokinetics of dextromethorphan (model substrate of metabolism by CYP 450). Dextromethorphan was used as surrogate marker of CYP2D1 activity as it is preferentially metabolised via O-demethylation by CYP2D1 to its primary metabolite dextrorphan (DOR). CYP3A4 is responsible for N-demethylation of DEM to methoxymorphinan and of DOR to hydroxymorphinan. CYP2D1 is the homolog of human CYP2D6. Fluoxetine has been reported to be of therapeutic benefit in the treatment of alcoholism; it was the aim of the present study to compare the effect of fluoxetine (20mg/kg for 6 days i.p.)in the rats pretreated by methamphetamine (10mg/kg for 6 days i.p.), as well as to answer the question if fluoxetin may be used for the characterization of novel pharmacotherapy in methamphetamine dependence. Fluoxetine in our experiments inhibited metabolism by the CYP2D1 and the CYP3A4. Methamphetamine stimulated metabolism mediated by the CYP2D1 but not by the CYP3A4. Combination of drugs inhibited oxidative metabolism by the CYP2D1 but stimulate alternative pathway of metabolism by the CYP3A4. The results suggest that fluoxetine therapy in methamphetamine dependence could slow down biodegradation of methamphetamine and this would enable to reduce methamphetamine doses without a decrease in psychotropic effect of the drug. ER -
DOSTÁLEK, Miroslav, Jiří SLÍVA, Eva HADAŠOVÁ a Josef TOMANDL. Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine. \textit{Bratislavské lekárské listy}. Bratislava: Slovak Academic Press, s.r.o. Bratislava, 2002, roč.~103, č.~9, s.~310-310. ISSN~0006-9248.
|