FAJKUS, Jiří, Marta ŠIMÍČKOVÁ and Jan MALÁSKA. Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. Phil. Trans. R. Soc. Lond. B, London: ROYAL SOC LONDON, 2002, roč. 357, April, p. 545-562. ISSN 0962-8436.
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Basic information
Original name Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
Authors FAJKUS, Jiří (203 Czech Republic, guarantor), Marta ŠIMÍČKOVÁ (203 Czech Republic) and Jan MALÁSKA (203 Czech Republic).
Edition Phil. Trans. R. Soc. Lond. B, London, ROYAL SOC LONDON, 2002, 0962-8436.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.410
RIV identification code RIV/00216224:14310/02:00006954
Organization unit Faculty of Science
UT WoS 000175540200009
Keywords in English human telomere; telomerase regulation; cancer; inhibiotin; cell engineering; tissue engineering
Tags cancer, cell engineering, human telomere, inhibiotin, telomerase regulation, tissue engineering
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Jiří Fajkus, CSc., učo 28574. Changed: 30/6/2009 12:49.
Abstract
The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively.
Links
GA301/99/0045, research and development projectName: Dynamika telomer u vybraných typů solidních maligních onemocnění
Investor: Czech Science Foundation, Standard Projects
IBS5004010, research and development projectName: Vývoj nových diagnostických technik pro onkologii
Investor: Academy of Sciences of the Czech Republic, Programme of Targeted Research and Development Support
MSM 143100008, plan (intention)Name: Genomy a jejich funkce
Investor: Ministry of Education, Youth and Sports of the CR, Research Intents
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