NOVÁKOVÁ, Marie. The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation. Physiological Research. Praha: Inst of Physiology, Academy of Sciences, 2002, roč. 51, č. 4, s. 29P, 1 s. ISSN 0862-8408. |
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@article{407493, author = {Nováková, Marie}, article_location = {Praha}, article_number = {4}, keywords = {guinea pig; atrium; sigma receptor; haloperidol; mechanical restitution}, language = {eng}, issn = {0862-8408}, journal = {Physiological Research}, title = {The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation}, volume = {51}, year = {2002} }
TY - JOUR ID - 407493 AU - Nováková, Marie PY - 2002 TI - The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation JF - Physiological Research VL - 51 IS - 4 SP - 29P EP - 29P PB - Inst of Physiology, Academy of Sciences SN - 08628408 KW - guinea pig KW - atrium KW - sigma receptor KW - haloperidol KW - mechanical restitution N2 - Our previous experiments with sigma receptor ligands in rat myocytes and rat isolated hearts suggested that these receptors may play a role in modulation of contractility. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on the amplitude of contraction and on the restitution of contractility were investigated. The positive inotropic effect of haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration. ER -
NOVÁKOVÁ, Marie. The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation. \textit{Physiological Research}. Praha: Inst of Physiology, Academy of Sciences, 2002, roč.~51, č.~4, s.~29P, 1 s. ISSN~0862-8408.
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