MITCHELL, Edward, Corinne HOULES, Dvora SUDAKEVITZ, Michaela WIMMEROVÁ, Catherine GAUTIER, Serge PÉREZ, Albert M. WU, Nechama GILBOA-GARBER a Anne IMBERTY. Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. Nature Structural Biology. New York: Nature America Inc., 2002, roč. 9, č. 12, s. 918-921. ISSN 1072-8368. |
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@article{407796, author = {Mitchell, Edward and Houles, Corinne and Sudakevitz, Dvora and Wimmerová, Michaela and Gautier, Catherine and Pérez, Serge and Wu, Albert M. and GilboaandGarber, Nechama and Imberty, Anne}, article_location = {New York}, article_number = {12}, keywords = {lectin; Pseudomonas aeruginosa; cystic fibrosis; crystal structure}, language = {eng}, issn = {1072-8368}, journal = {Nature Structural Biology}, title = {Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients}, volume = {9}, year = {2002} }
TY - JOUR ID - 407796 AU - Mitchell, Edward - Houles, Corinne - Sudakevitz, Dvora - Wimmerová, Michaela - Gautier, Catherine - Pérez, Serge - Wu, Albert M. - Gilboa-Garber, Nechama - Imberty, Anne PY - 2002 TI - Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients JF - Nature Structural Biology VL - 9 IS - 12 SP - 918 EP - 918 PB - Nature America Inc. SN - 10728368 KW - lectin KW - Pseudomonas aeruginosa KW - cystic fibrosis KW - crystal structure N2 - Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Lea) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics. ER -
MITCHELL, Edward, Corinne HOULES, Dvora SUDAKEVITZ, Michaela WIMMEROVÁ, Catherine GAUTIER, Serge PÉREZ, Albert M. WU, Nechama GILBOA-GARBER a Anne IMBERTY. Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. \textit{Nature Structural Biology}. New York: Nature America Inc., 2002, roč.~9, č.~12, s.~918-921. ISSN~1072-8368.
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