Detailed Information on Publication Record
2003
C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer
BENEŠ, Petr, Michal JURAJDA, Jan ŽALOUDÍK, Lydie IZAKOVIČOVÁ HOLLÁ, Jiří VÁCHA et. al.Basic information
Original name
C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer
Name in Czech
Genový polymorfismus C766T v genu pro low-density lipoprotein receptor-related protein 1 ( LRP1) a náchylnost ke karcinomu prsu
Authors
BENEŠ, Petr (203 Czech Republic, guarantor), Michal JURAJDA (203 Czech Republic), Jan ŽALOUDÍK (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)
Edition
Breast Cancer Research, 2003, 1465-542X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.932
RIV identification code
RIV/00216224:14110/03:00009856
Organization unit
Faculty of Medicine
UT WoS
000183439400004
Keywords in English
breast cancer; case-control study; genetic polymorphism; low-density lipoprotein receptor-related protein 1
Tags
International impact, Reviewed
Změněno: 17/6/2009 12:32, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.
V originále
Background: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression. Methods: We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease. Results: An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P=0.01963). A significant excess of genotypes with the T allele (homozygotes plus heterozygotes) was also observed (odds ratio 1.743, 95% confidence interval 1.112-2.732). Conclusion: The T allele of the C766T polymorphism in the LRP1 gene is associated with an increased risk of breast cancer development in women of Caucasian origin.
In Czech
"Low-density lipoprotein receptor-related protein 1" (LRP1) je multifunkční endocytický receptor s důležitou rolí při regulaci aktivity proteáz v extracelulární matrix. Několik studií popsalo také jeho roli ve vnitrobuněčné signalizaci. Bylo prokázáno, že exprese LRP1 má vztah k invazivitě nádorových buněk. Podle nedávných zjištění se však LRP1 může podílet také na nádorové transformaci buněk. V naší práci jsme studovali asociaci mezi genovým polymorfizmem C766T ve třetím exonu genu pro LRP1 a karcinomem prsu na vzorku žen indoevropské rasy. Alelické a genotypové frekvence sledovaného polymorfizmu byly určeny u 164 žen s karcinomem prsu a u 183 věkově odpovídajících kontrol. Mezi ženami s karcinomem prsu byla pozorována větší četnost alely T sledovaného polymorfizmu v porovnání s kontrolní populací (0.21 versus 0.15, P=0.01963). Bylo pozorováno také signifikantně větší zastoupení nositelek alespoň jedné T alely (homozygotů a heterozygotů) mezi pacientkami s karcinomem prsu (poměr šancí 1.743, 95% interval spolehlivosti 1.112-2.732). Alela T polymorfizmu C766T v LRP1 genu je asociována se zvýšeným rizikem rozvoje karcinomu prsu u žen indoevropské rasy.
Links
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