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@article{488505,
author = {Pistovčáková, Jana and Šulcová, Alexandra},
article_number = {Suppl.1},
keywords = {olfactory bulbectomy; amisulpride; antidepressant},
language = {eng},
issn = {0955-8810},
journal = {Behavioural Pharmacology},
title = {EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION},
volume = {14},
year = {2003}
}
TY - JOUR
ID - 488505
AU - Pistovčáková, Jana - Šulcová, Alexandra
PY - 2003
TI - EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION
JF - Behavioural Pharmacology
VL - 14
IS - Suppl.1
SP - 40-40
EP - 40-40
PB - Lippincott Williams & Wilkinks
SN - 09558810
KW - olfactory bulbectomy
KW - amisulpride
KW - antidepressant
N2 - Amisulpride, an atypical antipsychotic agent, in low doses preferentially blocks D2 and D3 dopamine autoreceptors in the limbic system. In our pre-clinical experiment we used the bilaterally-bulbectomized rat model of depression to examine whether amisulpride reduces the characteristic hyperactive locomotor responses in these rats exposed in the open-field test. Apart from the behavioural changes also amisulpride effects on the immune function of leukocyte phagocytosis in both sham-operated and bulbectomized rats were tested. Leukocyte zymosan induced phagocytosis was evaluated according to luminol aided chemiluminescence in vitro after repeated administration of amisulpride in vivo. OB rats showed a significant increase in ambulation and rearing scores in the open-field test, and suppressed leukocyte phagocytic function compared to the sham-operated rats. Repeated amisulpride administration (7mg/kg/day, intraperitoneally, for 7 days) resulted in a significant suppression of the motor hyperactivity of the OB rats in the open field test. On the day 7 of the amisulpride treatment, there was no significant difference in the distance travelled in the tracking arena between the OB and the sham-operated groups of rats, neither in the 3-min, nor in the 5-min intervals. Amisulpride (7mg/kg/day) after 7 days of administration significantly suppressed chemiluminescence kinetic curve (measurement every 5th min during 1 h) in the sham-operated rats but did not change the inhibited leukocyte phagocytosis in the OB rats. This did not indicate amisulpride positive influence on this immune disorder caused by OB. Thus, only the results of the behavioural experiment support the hypothesized antidepressant activity of amisulpride in the present study.
ER -
PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION. \textit{Behavioural Pharmacology}. Lippincott Williams \&{} Wilkinks, 2003, roč.~14, Suppl.1, s.~40-40. ISSN~0955-8810.
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