Pretreatment with cannabinoid receptor agonist and antagonist
increases and decreases, respectively, sensitization to
methamphetamine stimulation of mouse locomtor behaviour

J 2003

Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour

LANDA, Leoš; Alexandra ŠULCOVÁ a Karel ŠLAIS

Základní údaje

Originální název

Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour

Autoři

LANDA, Leoš; Alexandra ŠULCOVÁ a Karel ŠLAIS

Vydání

Behavioural Pharmacology, London, UK, Lippincott Williams & Wilkins, 2003, 0955-8810

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.375

Kód RIV

RIV/00216224:14110/03:00008969

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice

Štítky

AM 251, behavioural sensitization, locomotion, methamphetamine, methanandamide, mice

Příznaky

Mezinárodní význam

Změněno: 30. 11. 2006 13:23, doc. Mgr. MVDr. Leoš Landa, Ph.D.

Anotace

V originále

In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals.

Citovat

LANDA, Leoš; Alexandra ŠULCOVÁ a Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. Behavioural Pharmacology. London, UK: Lippincott Williams & Wilkins, 2003, roč. 14, Suppl. 1, s. 60 - 60. ISSN 0955-8810.

@article{489442,
   author = {Landa, Leoš and Šulcová, Alexandra and Šlais, Karel},
   article_location = {London, UK},
   article_number = {Suppl. 1},
   keywords = {Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice},
   language = {eng},
   issn = {0955-8810},
   journal = {Behavioural Pharmacology},
   title = {Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour},
   volume = {14},
   year = {2003}
}

TY  - JOUR
ID  - 489442
AU  - Landa, Leoš - Šulcová, Alexandra - Šlais, Karel
PY  - 2003
TI  - Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour
JF  - Behavioural Pharmacology
VL  - 14
IS  - Suppl. 1
SP  - 60 - 60
EP  - 60 - 60
PB  - Lippincott Williams & Wilkins
SN  - 09558810
KW  - Behavioural sensitization
KW  - AM 251
KW  - methamphetamine
KW  - methanandamide
KW  - locomotion
KW  - mice
N2  - In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals.
ER  -

LANDA, Leoš; Alexandra ŠULCOVÁ a Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. \textit{Behavioural Pharmacology}. London, UK: Lippincott Williams \&{} Wilkins, 2003, roč.~14, Suppl. 1, s.~60 - 60. ISSN~0955-8810.

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