IZAKOVIČOVÁ HOLLÁ, Lydie, Michal JURAJDA, Antonín FASSMANN, Naděžda DVOŘÁKOVÁ, Vladimír ZNOJIL and Jiří VÁCHA. Genetic variations in the matrix metalloproteinase-1 (MMP-1) promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population. J Clin Periodontol. Denmark: Munksgaard International Publishers Ltd., 2004, vol. 31, No 8, p. 685-690. ISSN 0303-6979.
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Basic information
Original name Genetic variations in the matrix metalloproteinase-1 (MMP-1) promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population
Name in Czech Genetické varianty v promotoru genu pro matrix metaloproteinázu 1 (MMP-1) a riziko náchylnosti ke vzniku/a nebo závažnosti chronické parodontitidy v české populaci
Authors IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Michal JURAJDA (203 Czech Republic), Antonín FASSMANN (203 Czech Republic), Naděžda DVOŘÁKOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition J Clin Periodontol, Denmark, Munksgaard International Publishers Ltd. 2004, 0303-6979.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Denmark
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.644
RIV identification code RIV/00216224:14110/04:00009879
Organization unit Faculty of Medicine
UT WoS 000222713500016
Keywords in English periodontitis; MMP-1; matrix metalloproteinase; haplotype; gene
Tags gene, haplotype, matrix metalloproteinase, MMP-1, periodontitis
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 11:52.
Abstract
Matrix metalloproteinase-1 (MMP-1) is a potent enzyme degrading extracellular matrix, which was implicated in the pathogenesis of chronic periodontitis. Therefore, the aim of our study was to examine the association between three promoter polymorphisms of the MMP-1 gene and chronic periodontitis susceptibility and/or severity in a Czech population.
Abstract (in Czech)
Matrix metaloproteináza 1 (MMP-1) je enzym degradující extracelulární matrix, který se účastní patogeneze chronické parodontitidy. Cílem naší práce bylo analyzovat asociaci mezi třemi promotorovými polymorfizmy v genu pro MMP-1 a náchylností ke vzniku chronické parodontitidy a/nebo její závažnosti v české populaci.
Links
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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