c-Fos but not v-Fos protein induces programmed cell death of
v-myb-transformed monoblasts

J 2003

c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts

ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Sabina ŠEVČÍKOVÁ, Jana ŠMARDOVÁ, Jan ŠMARDA et. al.

Základní údaje

Originální název

c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts

Autoři

ZAHRADNÍČKOVÁ, Eva (203 Česká republika), Karel SOUČEK (203 Česká republika), Sabina ŠEVČÍKOVÁ (203 Česká republika), Jana ŠMARDOVÁ (203 Česká republika) a Jan ŠMARDA (203 Česká republika, garant)

Vydání

Cellular and Molecular Life Sciences, Bäsel, Birkhaeuser Verlag, 2003, 1420-682X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.995

Kód RIV

RIV/00216224:14310/03:00008450

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000187503800015

Klíčová slova anglicky

Fos; Jun; AP-1; v-Myb; apoptosis; differentiation; proliferation; cell cycle

Štítky

AP-1, apoptosis, cell cycle, differentiation, Fos, Jun, proliferation, v-Myb

Změněno: 17. 2. 2009 08:17, prof. RNDr. Jan Šmarda, CSc.

Anotace

V originále

c-Fos and v-Fos belong to a group of proteins forming the transcription factor AP-1 that is important for differentiation, proliferation and apoptosis in multiple cell types. In this study, we examined the role of c-Fos and v-Fos proteins in v-myb-transformed BM2 monoblats. We show that while the v-Fos protein prolongs the G0G1 phase of the BM2 cell cycle, c-Fos leaves the cell cycle unaffected and, rather, induces programmed cell death. The apoptosis promoting activity of the c-Fos protein is markedly enhanced in cells cultivated under serum-free conditions. c-Fos-induced apoptosis occurred in the presence of Bcl-2 and was not dependent on the transcription activation function of the c-Fos protein. No differentiation-promoting activity of the Fos proteins was observed. The effects of Fos proteins on BM2 cells differ from those induced by Jun proteins, suggesting differential roles of individual components of the AP-1 transcription factor in regulation essential cellular processes.

Návaznosti

GA301/01/0040, projekt VaV

Název: Úloha proteinů Fos a Jun v monocytické diferenciaci stimulované kyselinou retinovou

Investor: Grantová agentura ČR, Úloha proteinů Fos a Jun v monocytické diferenciaci stimulované kyselinou retinovou

GA301/03/1055, projekt VaV

Název: Studium molekulárních mechanismů způsobujících supresi v-Myb s využitím přístupů proteomiky

Investor: Grantová agentura ČR, Studium molekulárních mechanismů způsobujících supresi v-Myb s využitím přístupů proteomiky

MSM 143100008, záměr

Název: Genomy a jejich funkce

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Genomy a jejich funkce

Citovat

ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Sabina ŠEVČÍKOVÁ, Jana ŠMARDOVÁ a Jan ŠMARDA. c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. Cellular and Molecular Life Sciences. Bäsel: Birkhaeuser Verlag, 2003, roč. 60, č. 12, s. 2736-2748. ISSN 1420-682X.

@article{491699,
   author = {Zahradníčková, Eva and Souček, Karel and Ševčíková, Sabina and Šmardová, Jana and Šmarda, Jan},
   article_location = {Bäsel},
   article_number = {12},
   keywords = {Fos; Jun; AP-1; v-Myb; apoptosis; differentiation; proliferation; cell cycle},
   language = {eng},
   issn = {1420-682X},
   journal = {Cellular and Molecular Life Sciences},
   title = {c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts},
   volume = {60},
   year = {2003}
}

TY  - JOUR
ID  - 491699
AU  - Zahradníčková, Eva - Souček, Karel - Ševčíková, Sabina - Šmardová, Jana - Šmarda, Jan
PY  - 2003
TI  - c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts
JF  - Cellular and Molecular Life Sciences
VL  - 60
IS  - 12
SP  - 2736-2748
EP  - 2736-2748
PB  - Birkhaeuser Verlag
SN  - 1420682X
KW  - Fos
KW  - Jun
KW  - AP-1
KW  - v-Myb
KW  - apoptosis
KW  - differentiation
KW  - proliferation
KW  - cell cycle
N2  - c-Fos and v-Fos belong to a group of proteins forming the transcription factor AP-1 that is important for differentiation, proliferation and apoptosis in multiple cell types. In this study, we examined the role of c-Fos and v-Fos proteins in v-myb-transformed BM2 monoblats. We show that while the v-Fos protein prolongs the G0G1 phase of the BM2 cell cycle, c-Fos leaves the cell cycle unaffected and, rather, induces programmed cell death. The apoptosis promoting activity of the c-Fos protein is markedly enhanced in cells cultivated under serum-free conditions. c-Fos-induced apoptosis occurred in the presence of Bcl-2 and was not dependent on the transcription activation function of the c-Fos protein. No differentiation-promoting activity of the Fos proteins was observed. The effects of Fos proteins on BM2 cells differ from those induced by Jun proteins, suggesting differential roles of individual components of the AP-1 transcription factor in regulation essential cellular processes.
ER  -

ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Sabina ŠEVČÍKOVÁ, Jana ŠMARDOVÁ a Jan ŠMARDA. c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. \textit{Cellular and Molecular Life Sciences}. Bäsel: Birkhaeuser Verlag, 2003, roč.~60, č.~12, s.~2736-2748. ISSN~1420-682X.

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