| ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Sabina ŠEVČÍKOVÁ, Jana ŠMARDOVÁ a Jan ŠMARDA. c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. Cellular and Molecular Life Sciences. Bäsel: Birkhaeuser Verlag, 2003, roč. 60, č. 12, s. 2736-2748. ISSN 1420-682X. |
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@article{491699,
author = {Zahradníčková, Eva and Souček, Karel and Ševčíková, Sabina and Šmardová, Jana and Šmarda, Jan},
article_location = {Bäsel},
article_number = {12},
keywords = {Fos; Jun; AP-1; v-Myb; apoptosis; differentiation; proliferation; cell cycle},
language = {eng},
issn = {1420-682X},
journal = {Cellular and Molecular Life Sciences},
title = {c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts},
volume = {60},
year = {2003}
}
TY - JOUR
ID - 491699
AU - Zahradníčková, Eva - Souček, Karel - Ševčíková, Sabina - Šmardová, Jana - Šmarda, Jan
PY - 2003
TI - c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts
JF - Cellular and Molecular Life Sciences
VL - 60
IS - 12
SP - 2736-2748
EP - 2736-2748
PB - Birkhaeuser Verlag
SN - 1420682X
KW - Fos
KW - Jun
KW - AP-1
KW - v-Myb
KW - apoptosis
KW - differentiation
KW - proliferation
KW - cell cycle
N2 - c-Fos and v-Fos belong to a group of proteins forming the transcription factor AP-1 that is important for differentiation, proliferation and apoptosis in multiple cell types. In this study, we examined the role of c-Fos and v-Fos proteins in v-myb-transformed BM2 monoblats. We show that while the v-Fos protein prolongs the G0G1 phase of the BM2 cell cycle, c-Fos leaves the cell cycle unaffected and, rather, induces programmed cell death. The apoptosis promoting activity of the c-Fos protein is markedly enhanced in cells cultivated under serum-free conditions. c-Fos-induced apoptosis occurred in the presence of Bcl-2 and was not dependent on the transcription activation function of the c-Fos protein. No differentiation-promoting activity of the Fos proteins was observed. The effects of Fos proteins on BM2 cells differ from those induced by Jun proteins, suggesting differential roles of individual components of the AP-1 transcription factor in regulation essential cellular processes.
ER -
ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Sabina ŠEVČÍKOVÁ, Jana ŠMARDOVÁ a Jan ŠMARDA. c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. \textit{Cellular and Molecular Life Sciences}. Bäsel: Birkhaeuser Verlag, 2003, roč.~60, č.~12, s.~2736-2748. ISSN~1420-682X.
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