c-Fos but not v-Fos protein induces programmed cell death of
v-myb-transformed monoblasts

J 2003

c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts

ZAHRADNÍČKOVÁ, Eva; Karel SOUČEK; Sabina ŠEVČÍKOVÁ; Jana ŠMARDOVÁ; Jan ŠMARDA et. al.

Basic information

Original name

c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts

Authors

ZAHRADNÍČKOVÁ, Eva (203 Czech Republic); Karel SOUČEK (203 Czech Republic); Sabina ŠEVČÍKOVÁ (203 Czech Republic); Jana ŠMARDOVÁ (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor)

Edition

Cellular and Molecular Life Sciences, Bäsel, Birkhaeuser Verlag, 2003, 1420-682X

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

Genetics and molecular biology

Country of publisher

Switzerland

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 4.995

RIV identification code

RIV/00216224:14310/03:00008450

Organization unit

Faculty of Science

UT WoS

000187503800015

Keywords in English

Fos; Jun; AP-1; v-Myb; apoptosis; differentiation; proliferation; cell cycle

Abstract

In the original language

c-Fos and v-Fos belong to a group of proteins forming the transcription factor AP-1 that is important for differentiation, proliferation and apoptosis in multiple cell types. In this study, we examined the role of c-Fos and v-Fos proteins in v-myb-transformed BM2 monoblats. We show that while the v-Fos protein prolongs the G0G1 phase of the BM2 cell cycle, c-Fos leaves the cell cycle unaffected and, rather, induces programmed cell death. The apoptosis promoting activity of the c-Fos protein is markedly enhanced in cells cultivated under serum-free conditions. c-Fos-induced apoptosis occurred in the presence of Bcl-2 and was not dependent on the transcription activation function of the c-Fos protein. No differentiation-promoting activity of the Fos proteins was observed. The effects of Fos proteins on BM2 cells differ from those induced by Jun proteins, suggesting differential roles of individual components of the AP-1 transcription factor in regulation essential cellular processes.

Links

GA301/01/0040, research and development project

Name: Úloha proteinů Fos a Jun v monocytické diferenciaci stimulované kyselinou retinovou

Investor: Czech Science Foundation, The Role of Fos and Jun proteins in RA-driven monocytic differentiation

GA301/03/1055, research and development project

Name: Studium molekulárních mechanismů způsobujících supresi v-Myb s využitím přístupů proteomiky

Investor: Czech Science Foundation, Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach

MSM 143100008, plan (intention)

Name: Genomy a jejich funkce

Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions

Cite

ZAHRADNÍČKOVÁ, Eva; Karel SOUČEK; Sabina ŠEVČÍKOVÁ; Jana ŠMARDOVÁ and Jan ŠMARDA. c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. Cellular and Molecular Life Sciences. Bäsel: Birkhaeuser Verlag, 2003, vol. 60, No 12, p. 2736-2748. ISSN 1420-682X.

@article{491699,
   author = {Zahradníčková, Eva and Souček, Karel and Ševčíková, Sabina and Šmardová, Jana and Šmarda, Jan},
   article_location = {Bäsel},
   article_number = {12},
   keywords = {Fos; Jun; AP-1; v-Myb; apoptosis; differentiation; proliferation; cell cycle},
   language = {eng},
   issn = {1420-682X},
   journal = {Cellular and Molecular Life Sciences},
   title = {c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts},
   volume = {60},
   year = {2003}
}

TY  - JOUR
ID  - 491699
AU  - Zahradníčková, Eva - Souček, Karel - Ševčíková, Sabina - Šmardová, Jana - Šmarda, Jan
PY  - 2003
TI  - c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts
JF  - Cellular and Molecular Life Sciences
VL  - 60
IS  - 12
SP  - 2736-2748
EP  - 2736-2748
PB  - Birkhaeuser Verlag
SN  - 1420682X
KW  - Fos
KW  - Jun
KW  - AP-1
KW  - v-Myb
KW  - apoptosis
KW  - differentiation
KW  - proliferation
KW  - cell cycle
N2  - c-Fos and v-Fos belong to a group of proteins forming the transcription factor AP-1 that is important for differentiation, proliferation and apoptosis in multiple cell types. In this study, we examined the role of c-Fos and v-Fos proteins in v-myb-transformed BM2 monoblats. We show that while the v-Fos protein prolongs the G0G1 phase of the BM2 cell cycle, c-Fos leaves the cell cycle unaffected and, rather, induces programmed cell death. The apoptosis promoting activity of the c-Fos protein is markedly enhanced in cells cultivated under serum-free conditions. c-Fos-induced apoptosis occurred in the presence of Bcl-2 and was not dependent on the transcription activation function of the c-Fos protein. No differentiation-promoting activity of the Fos proteins was observed. The effects of Fos proteins on BM2 cells differ from those induced by Jun proteins, suggesting differential roles of individual components of the AP-1 transcription factor in regulation essential cellular processes.
ER  -

ZAHRADNÍČKOVÁ, Eva; Karel SOUČEK; Sabina ŠEVČÍKOVÁ; Jana ŠMARDOVÁ and Jan ŠMARDA. c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. \textit{Cellular and Molecular Life Sciences}. Bäsel: Birkhaeuser Verlag, 2003, vol.~60, No~12, p.~2736-2748. ISSN~1420-682X.

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