Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

ZAHRADNÍČKOVÁ, Eva, Sabina ŠEVČÍKOVÁ, Karel SOUČEK a Jan ŠMARDA. Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts. In Memory in Living Systems. Brno: Czechoslovak Biological Society, 2003, s. 73. ISBN 80-210-3264-2.

Základní údaje

• Originální název: Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
• Název anglicky: Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
• Autoři: ZAHRADNÍČKOVÁ, Eva (203 Česká republika), Sabina ŠEVČÍKOVÁ (203 Česká republika), Karel SOUČEK (203 Česká republika) a Jan ŠMARDA (203 Česká republika, garant).
• Vydání: Brno, Memory in Living Systems, s. 73-73, 2003.
• Nakladatel: Czechoslovak Biological Society

Další údaje

• Originální jazyk: čeština
• Typ výsledku: Stať ve sborníku
• Obor: Genetika a molekulární biologie
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• Kód RIV: RIV/00216224:14330/03:00008669
• Organizační jednotka: Fakulta informatiky
• ISBN: 80-210-3264-2
• Klíčová slova anglicky: Fos; Myb; proliferation; differentiation; apoptosis
• Štítky: apoptosis, differentiation, Fos, Myb, proliferation

Anotace

c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.

Anotace anglicky

c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.

Návaznosti

• GA301/01/0040, projekt VaV: Název: Úloha proteinů Fos a Jun v monocytické diferenciaci stimulované kyselinou retinovou

Investor: Grantová agentura ČR, Úloha proteinů Fos a Jun v monocytické diferenciaci stimulované kyselinou retinovou

• GA301/03/1055, projekt VaV: Název: Studium molekulárních mechanismů způsobujících supresi v-Myb s využitím přístupů proteomiky

Investor: Grantová agentura ČR, Studium molekulárních mechanismů způsobujících supresi v-Myb s využitím přístupů proteomiky