PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Antidepressant-like effects of tiagabine on locomotor/exploratory behaviour and leukocyte phagocytosis in rats. European Neuropsychopharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2004, roč. 14, Suppl.1, s. S41-S42, 2 s. ISSN 0924-977X. |
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@article{555219, author = {Pistovčáková, Jana and Šulcová, Alexandra}, article_location = {Amsterdam, The Netherlands}, article_number = {Suppl.1}, keywords = {animal model; depression; olfactory bulbectomy; tiagabine}, language = {eng}, issn = {0924-977X}, journal = {European Neuropsychopharmacology}, title = {Antidepressant-like effects of tiagabine on locomotor/exploratory behaviour and leukocyte phagocytosis in rats}, volume = {14}, year = {2004} }
TY - JOUR ID - 555219 AU - Pistovčáková, Jana - Šulcová, Alexandra PY - 2004 TI - Antidepressant-like effects of tiagabine on locomotor/exploratory behaviour and leukocyte phagocytosis in rats JF - European Neuropsychopharmacology VL - 14 IS - Suppl.1 SP - S41-S42 EP - S41-S42 PB - Elsevier Science B.V. SN - 0924977X KW - animal model KW - depression KW - olfactory bulbectomy KW - tiagabine N2 - The purpose of the study was to test a potential antidepressant effect of the 3rd generation antiepileptic tiagabine in rats with bilateral olfactory bulbectomy (OB), which is a well-established animal model of human depression resembling behavioural, immune and endocrine changes. In rats we examined tiagabine effect on locomotor/exploratory activities in the open-field test, and on phagocytosis of leukocytes. Compared to the sham-operated animals OB rats showed a characteristic locomotor hyperactivity in the open-field and a significant suppression of leukocyte phagocytosis. Repeated tiagabine treatment (12 mg/kg/day, 10 days, intraperitoneally) elicited a significant decrease of the locomotor hyperactivity in the open field test, and significant disinhibition of leukocyte phagocytosis. Taking into account that clinically approved antidepressants reverse OB related behavioural and immune disorders (Leonard and Tuite, 1981) the results of both present experiments indicate the hypothesized antidepressant activity of tiagabine. ER -
PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Antidepressant-like effects of tiagabine on locomotor/exploratory behaviour and leukocyte phagocytosis in rats. \textit{European Neuropsychopharmacology}. Amsterdam, The Netherlands: Elsevier Science B.V., 2004, roč.~14, Suppl.1, s.~S41-S42, 2 s. ISSN~0924-977X.
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