Kinetic Complexation and Decomplexation Study of
1,8-bis(methylphosphonic) Derivatives with Some Metal Ions

D 2003

Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL et. al.

Základní údaje

Originální název

Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions

Autoři

SVOBODOVÁ, Ivona (203 Česká republika, garant), Přemysl LUBAL (203 Česká republika), Jan KOTEK (203 Česká republika), Petr HERMANN (203 Česká republika), Josef HAVEL (203 Česká republika) a Ivan LUKEŠ (203 Česká republika)

Vydání

Gdansk, Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003, od s. P118, 1 s. 2003

Nakladatel

Gdansk University of Technology

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10406 Analytical chemistry

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/03:00008744

Organizační jednotka

Přírodovědecká fakulta

ISBN

83-914495-6-4

Klíčová slova anglicky

1;8-BIS(METHYLPHOSPHONIC) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics; PET;

Štítky

1, 8-BIS(METHYLPHOSPHONIC) CYCLAM DERIVATIVES, copper(II) complexes, kinetics, PET, Thermodynamics

Změněno: 31. 5. 2004 15:31, prof. RNDr. Přemysl Lubal, Ph.D.

Anotace

V originále

Macrocyclic ligands are used as bifunctional chelating agents in nuclear medicine, e. g. in radioisotope diagnostics (64Cu - Beta+ emitter) or in tumor radiotherapy (67Cu - Beta- emitter). For possible medical applications, it is necessary to know thermodynamic and kinetic properties (rate constants of formation and dissociation) of copper and biometal complexes under experimental conditions similar to body fluids. In this work, the formation and dissociation kinetics of complexes of transitional metal ions with ligands, 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dipon, H4L1) and 4,11-dimethyl-1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dimeMe2dipon, H4L2)was studied. The ligands form stable complexes with transitional metal ions Cu2+, Zn2+, Cd2+, Pb2+, Ca2+, Mg2+, Ni2+, Co2+. Formation (kf) and dissociation (kd) constants of Cu2+, Zn2+ and Cd2+ complexes with ligands dipon and dimeMe2dipon were measured under experimental conditions (t = 25oC, I = 0,1 mol.l-1). The formation and dissociation of metal complex of both ligands were explained and reaction mechanisms were postulated. The highest stability (kinetic as well as thermodynamic) is demonstrated by both ligands for copper(II), while the complex is already formed in solutions with pH lower than 2. The formation rate of copper complex of both ligands complex is 1000 times higher than complexes with the other studied ions. The dissociation of this complex takes place at lower pH than complexes with the other studied ions.

Návaznosti

GA203/02/0493, projekt VaV

Název: Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

Investor: Grantová agentura ČR, Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

GA203/03/0168, projekt VaV

Název: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia

MSM 143100011, záměr

Název: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Citovat

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL a Ivan LUKEŠ. Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions. In Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003. Gdansk: Gdansk University of Technology, 2003, s. P118, 1 s. ISBN 83-914495-6-4.

@inproceedings{555459,
   author = {Svobodová, Ivona and Lubal, Přemysl and Kotek, Jan and Hermann, Petr and Havel, Josef and Lukeš, Ivan},
   address = {Gdansk},
   booktitle = {Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003},
   keywords = {1;8-BIS(METHYLPHOSPHONIC) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics; PET;},
   language = {eng},
   location = {Gdansk},
   isbn = {83-914495-6-4},
   pages = {P118},
   publisher = {Gdansk University of Technology},
   title = {Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions},
   year = {2003}
}

TY  - JOUR
ID  - 555459
AU  - Svobodová, Ivona - Lubal, Přemysl - Kotek, Jan - Hermann, Petr - Havel, Josef - Lukeš, Ivan
PY  - 2003
TI  - Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions
PB  - Gdansk University of Technology
CY  - Gdansk
SN  - 8391449564
KW  - 1;8-BIS(METHYLPHOSPHONIC) CYCLAM DERIVATIVES
KW  - copper(II) complexes
KW  - thermodynamics
KW  - kinetics
KW  - PET;
N2  - Macrocyclic ligands are used as bifunctional chelating agents in nuclear medicine, e. g. in radioisotope diagnostics (64Cu - Beta+ emitter) or in tumor radiotherapy (67Cu - Beta- emitter). For possible medical applications, it is necessary to know thermodynamic and kinetic properties (rate constants of formation and dissociation) of copper and biometal complexes under experimental conditions similar to body fluids. In this work, the formation and dissociation kinetics of complexes of transitional metal ions with ligands, 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dipon, H4L1) and 4,11-dimethyl-1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dimeMe2dipon, H4L2)was studied. The ligands form stable complexes with transitional metal ions Cu2+, Zn2+, Cd2+, Pb2+, Ca2+, Mg2+, Ni2+, Co2+. Formation (kf) and dissociation (kd) constants of Cu2+, Zn2+ and Cd2+ complexes with ligands dipon and dimeMe2dipon were measured under experimental conditions (t = 25oC, I = 0,1 mol.l-1). The formation and dissociation of metal complex of both ligands were explained and reaction mechanisms were postulated. The highest stability (kinetic as well as thermodynamic) is demonstrated by both ligands for copper(II), while the complex is already formed in solutions with pH lower than 2. The formation rate of copper complex of both ligands complex is 1000 times higher than complexes with the other studied ions. The dissociation of this complex takes place at lower pH than complexes with the other studied ions.
ER  -

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL a Ivan LUKEŠ. Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions. In \textit{Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003}. Gdansk: Gdansk University of Technology, 2003, s.~P118, 1 s. ISBN~83-914495-6-4.

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