Comparative Study of Complexation and Dissociation Kinetics of
Yttrium(III) with DOTA-like Macrocylic Ligands

D 2003

Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands

MÁLKOVÁ, Michaela; Petr TÁBORSKÝ; Ivona SVOBODOVÁ; Přemysl LUBAL; Petr HERMANN et al.

Základní údaje

Originální název

Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands

Autoři

MÁLKOVÁ, Michaela; Petr TÁBORSKÝ; Ivona SVOBODOVÁ; Přemysl LUBAL; Petr HERMANN a Ivan LUKEŠ

Vydání

Geneve, Book of Abstracts of 5-th International Conference on f-elements - ICFE5. Geneva, Switzerland, August 24-29, 2003, od s. CO-P10, 1 s. 2003

Nakladatel

SYMPORG SA

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10406 Analytical chemistry

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/03:00008745

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

bifunctional chelating ligands; DOTA-like macrocyclic ligands; yttrium(III)

Štítky

bifunctional chelating ligands, DOTA-like macrocyclic ligands, yttrium(III)

Změněno: 31. 5. 2004 16:11, prof. RNDr. Přemysl Lubal, Ph.D.

Anotace

V originále

Bifunctional chelating ligands (BFC) sequestering radiometal ions are used in radioimunotherapy and diagnosis. BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules, e.g. monoclonal antibodies, small peptides, hormones, sugars, etc. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Both properties are strongly influenced by degree of derivatization of macrocyclic skeleton and type of linker attached to biomolecule. In this contribution, the influence of structural variation of linker of BFC on kinetic properties was studied. Under experimental conditions (t = 25 oC, I = 0.1 M KCl, pH = 5.6-7.1, cY = 7*10-7 M, cL = 1.6*10-5 M), which are closed to conditions of 90Y radiolabelling in nuclear medicine, the empirical order in reactivity in respect to yttrium(III) was obtained: DO3AP > DO3APPrA > DOTA > DO3A > DO3APABn The results of complexation kinetics were compared with data obtained for 90Y complexation by DO3APABn followed by radiometric method (cY = cL = 1.2*10-3 M, t = 25 oC, pH = 5.54) and both are in a good agreement. The results of dissociation kinetics of yttrium macrocyclic complexes are comparable with other lanthanide complexes.

Návaznosti

GA203/02/0493, projekt VaV

Název: Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

Investor: Grantová agentura ČR, Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

GA203/03/0168, projekt VaV

Název: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia

MSM 143100011, záměr

Název: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Citovat

MÁLKOVÁ, Michaela; Petr TÁBORSKÝ; Ivona SVOBODOVÁ; Přemysl LUBAL; Petr HERMANN a Ivan LUKEŠ. Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands. In Book of Abstracts of 5-th International Conference on f-elements - ICFE5. Geneva, Switzerland, August 24-29, 2003. Geneve: SYMPORG SA, 2003, s. CO-P10, 1 s.

@inproceedings{555466,
   author = {Málková, Michaela and Táborský, Petr and Svobodová, Ivona and Lubal, Přemysl and Hermann, Petr and Lukeš, Ivan},
   address = {Geneve},
   booktitle = {Book of Abstracts of 5-th International Conference on f-elements - ICFE5. Geneva, Switzerland, August 24-29, 2003},
   keywords = {bifunctional chelating ligands; DOTA-like macrocyclic ligands; yttrium(III)},
   language = {eng},
   location = {Geneve},
   pages = {CO-P10},
   publisher = {SYMPORG SA},
   title = {Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands},
   year = {2003}
}

TY  - CONF
ID  - 555466
AU  - Málková, Michaela - Táborský, Petr - Svobodová, Ivona - Lubal, Přemysl - Hermann, Petr - Lukeš, Ivan
PY  - 2003
TI  - Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands
PB  - SYMPORG SA
CY  - Geneve
KW  - bifunctional chelating ligands
KW  - DOTA-like macrocyclic ligands
KW  - yttrium(III)
N2  - Bifunctional chelating ligands (BFC) sequestering radiometal ions are used in radioimunotherapy and diagnosis. BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules, e.g. monoclonal antibodies, small peptides, hormones, sugars, etc. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Both properties are strongly influenced by degree of derivatization of macrocyclic skeleton and type of linker attached to biomolecule. In this contribution, the influence of structural variation of linker of BFC on kinetic properties was studied. Under experimental conditions (t = 25 oC, I = 0.1 M KCl, pH = 5.6-7.1, cY = 7*10-7 M, cL = 1.6*10-5 M), which are closed to conditions of 90Y radiolabelling in nuclear medicine, the empirical order in reactivity in respect to yttrium(III) was obtained: DO3AP > DO3APPrA > DOTA > DO3A > DO3APABn The results of complexation kinetics were compared with data obtained for 90Y complexation by DO3APABn followed by radiometric method (cY = cL = 1.2*10-3 M, t = 25 oC, pH = 5.54) and both are in a good agreement. The results of dissociation kinetics of yttrium macrocyclic complexes are comparable with other lanthanide complexes.
ER  -

MÁLKOVÁ, Michaela; Petr TÁBORSKÝ; Ivona SVOBODOVÁ; Přemysl LUBAL; Petr HERMANN a Ivan LUKEŠ. Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands. In \textit{Book of Abstracts of 5-th International Conference on f-elements - ICFE5. Geneva, Switzerland, August 24-29, 2003}. Geneve: SYMPORG SA, 2003, s.~CO-P10, 1 s.

Přehled o publikaci