| HOUŠTĚK, Josef, Karel VÍZEK, Stanislav PAVELKA, Jan KOPECKÝ, Ema KREJČOVÁ, Jana HEŘMANSKÁ a Miroslava ČERMÁKOVÁ. Type II iodothyronine 5'-deiodinase and uncoupling protein in brown adipose tissue of human newborns. Journal of Clinical Endocrinology and Metabolism [IF=4.220 (1992); SCI #cit.<30>]. 1993, roč. 77, č. 2, s. 382-387. ISSN 0021-972X. |
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@article{555626,
author = {Houštěk, Josef and Vízek, Karel and Pavelka, Stanislav and Kopecký, Jan and Krejčová, Ema and Heřmanská, Jana and Čermáková, Miroslava},
article_number = {2},
keywords = {Brown adipose tissue; human newborn; iodothyronine deiodinase; uncoupling protein},
language = {eng},
issn = {0021-972X},
journal = {Journal of Clinical Endocrinology and Metabolism [IF=4.220 (1992); SCI #cit.<30>]},
title = {Type II iodothyronine 5'-deiodinase and uncoupling protein in brown adipose tissue of human newborns},
volume = {77},
year = {1993}
}
TY - JOUR
ID - 555626
AU - Houštěk, Josef - Vízek, Karel - Pavelka, Stanislav - Kopecký, Jan - Krejčová, Ema - Heřmanská, Jana - Čermáková, Miroslava
PY - 1993
TI - Type II iodothyronine 5'-deiodinase and uncoupling protein in brown adipose tissue of human newborns
JF - Journal of Clinical Endocrinology and Metabolism [IF=4.220 (1992); SCI #cit.<30>]
VL - 77
IS - 2
SP - 382-387
EP - 382-387
SN - 0021972X
KW - Brown adipose tissue
KW - human newborn
KW - iodothyronine deiodinase
KW - uncoupling protein
N2 - Brown adipose tissue (BAT) from 13 newborns of 25-40 weeks gestational age who survived 4 days, at most, was investigated. BAT was found to contain significant amounts of the mitochondrial uncoupling protein (UCP), the rate-limiting component of heat production. BAT was also found to contain iodothyronine 5'-deiodinase (5'D), which appears to be a type II enzyme. The development of 5'D activity was similar to the changes in UCP content; both exhibited a major increase before 32 weeks gestation. The results indicate that thermogenic function and 5'D activity develop in human BAT rather early, during the first half of the last trimester of gestation.
ER -
HOUŠTĚK, Josef, Karel VÍZEK, Stanislav PAVELKA, Jan KOPECKÝ, Ema KREJČOVÁ, Jana HEŘMANSKÁ a Miroslava ČERMÁKOVÁ. Type II iodothyronine 5'-deiodinase and uncoupling protein in brown adipose tissue of human newborns. \textit{Journal of Clinical Endocrinology and Metabolism [IF=4.220 (1992); SCI \#{}cit.$<$30$>$]}. 1993, roč.~77, č.~2, s.~382-387. ISSN~0021-972X.
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