Sensitization and cannabinoid cross-sensitization to
methamphetamine antiaggressive effects is not developed in
morphine treatment design in mice

J 2004

Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice

ŠULCOVÁ, Alexandra, Leoš LANDA a Karel ŠLAIS

Základní údaje

Originální název

Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice

Název česky

SEnsitizace a krossensitizace kanabinoidem k inhibičnímu účinku metamfetaminu na agresivitu myší se nevzniká v řpípadě aplikace morfinu

Autoři

ŠULCOVÁ, Alexandra (203 Česká republika, garant), Leoš LANDA (203 Česká republika) a Karel ŠLAIS (203 Česká republika)

Vydání

Fundamental & Clinical Pharmacology, UK, Blackwll Publishing, 2004, 1744-3377

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/04:00010246

Organizační jednotka

Lékařská fakulta

UT WoS

000208663600308

Klíčová slova anglicky

cannabinoid; methamphetamine; morphine; sensitization

Štítky

cannabinoid, methamphetamine, morphine, sensitization

Změněno: 2. 9. 2004 13:59, prof. MUDr. Alexandra Šulcová, CSc.

Anotace

ORIG CZ

V originále

Repeated drug administration leading to a progressively enhanced response, a phenomenon termed sensitization, may be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. There also is data available showing a cross-sensitization between different types of drugs of abuse. The present study observed behavioural sensitization to the psychostimulant methamphetamine (MET), the opioid morphine (MO) and cross-sensitization with cannabinoid methanandamide (CA) to both of them in mice. The model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners was used to analyze behavioural changes in 15 acts of 4 categories: sociable, timid, aggressive and locomotor. Both MET and MO produce dose-dependent antiaggressive effects in singly-housed mice; MET increased while MO decreased locomotor activities. The sensitization to these effects of MET was clearly demonstrated when after the pre-treatment with 5 daily MET doses the challenge dose was given 5 days later, was suppressed by pretreatment with MET+cannabinoid antagonist AM 251, and cross-sensitization was present after the pretreatment with CA. In the same experimental design neither sensitization nor CA cross-sensitization to the antiaggressive efficacy of MO was registered. These results suggest an interaction between the endocannabinoid system and methamphetamine brain mechanisms, and support further the hypothesis that repeated use of cannabis may facilitate progression to the consumption of psychostimulants. The parallel was not confirmed with morphine.

Česky

Výsledky studie podporují údaje o funkční interakci mezi endokanabinoidním systémem a farmakologickými mechanismy účinku metamfetaminu. Paralela nebyla potvrzena u morfinu.

Citovat

ŠULCOVÁ, Alexandra, Leoš LANDA a Karel ŠLAIS. Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice. Fundamental & Clinical Pharmacology. UK: Blackwll Publishing, 2004, roč. 18, Suppl.1, s. 58. ISSN 1744-3377.

@article{557322,
   author = {Šulcová, Alexandra and Landa, Leoš and Šlais, Karel},
   article_location = {UK},
   article_number = {Suppl.1},
   keywords = {cannabinoid; methamphetamine; morphine; sensitization},
   language = {eng},
   issn = {1744-3377},
   journal = {Fundamental & Clinical Pharmacology},
   title = {Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice},
   volume = {18},
   year = {2004}
}

TY  - JOUR
ID  - 557322
AU  - Šulcová, Alexandra - Landa, Leoš - Šlais, Karel
PY  - 2004
TI  - Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice
JF  - Fundamental & Clinical Pharmacology
VL  - 18
IS  - Suppl.1
SP  - 58
EP  - 58
PB  - Blackwll Publishing
SN  - 17443377
KW  - cannabinoid
KW  - methamphetamine
KW  - morphine
KW  - sensitization
N2  - Repeated drug administration leading to a progressively enhanced response, a phenomenon termed sensitization, may be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. There also is data available showing a cross-sensitization between different types of drugs of abuse. The present study observed behavioural sensitization to the psychostimulant methamphetamine (MET), the opioid morphine (MO) and cross-sensitization with cannabinoid methanandamide (CA) to both of them in mice. The model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners was used to analyze behavioural changes in 15 acts of 4 categories: sociable, timid, aggressive and locomotor. Both MET and MO produce dose-dependent antiaggressive effects in singly-housed mice; MET increased while MO decreased locomotor activities. The sensitization to these effects of MET was clearly demonstrated when after the pre-treatment with 5 daily MET doses the challenge dose was given 5 days later, was suppressed by pretreatment with MET+cannabinoid antagonist AM 251, and cross-sensitization was present after the pretreatment with CA. In the same experimental design neither sensitization nor CA cross-sensitization to the antiaggressive efficacy of MO was registered. These results suggest an interaction between the endocannabinoid system and methamphetamine brain mechanisms, and support further the hypothesis that repeated use of cannabis may facilitate progression to the consumption of psychostimulants. The parallel was not confirmed with morphine.
ER  -

ŠULCOVÁ, Alexandra, Leoš LANDA a Karel ŠLAIS. Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice. \textit{Fundamental \&{} Clinical Pharmacology}. UK: Blackwll Publishing, 2004, roč.~18, Suppl.1, s.~58. ISSN~1744-3377.

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