Interaction of cannabinoid methanandamide with processes of
sensitization to both behavioral and immunological
methamphetamine effects in mice.

D 2004

Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice.

ŠULCOVÁ, Alexandra a Leoš LANDA

Základní údaje

Originální název

Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice.

Název česky

Interakce kanabinoidu metanandamidu s procesy sensitizace k behaviorálním a imunologickým účinklům metamfetaminu u myší

Autoři

ŠULCOVÁ, Alexandra (203 Česká republika, garant) a Leoš LANDA (203 Česká republika)

Vydání

USA, Abstracts - NIDA International Forum 2004, San Juan, Puerto Rico, s. 90-90, 2004

Nakladatel

US National Institute on Drug Abuse

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/04:00010248

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

methanandamide; methamphetamine; sensitization; mice

Štítky

methamphetamine, methanandamide, mice, sensitization

Změněno: 2. 9. 2004 14:20, prof. MUDr. Alexandra Šulcová, CSc.

Anotace

ORIG CZ

V originále

The phenomenon of sensitization enhancing usually stimulant behavioral response to repeatedly administered drugs of abuse has been described both in laboratory animals and human beings. There is also data available confirming a cross-sensitization between different types of drugs of abuse supporting further the hypothesis that repeated use of one drug of abuse may facilitate the consumption of other drugs. Previously we confirmed the sensitization to methamphetamine (MET) stimulatory effect on locomotor/exploratory behavior, and also to its inhibitory influence on aggression in mice. Furthermore, such sensitization was present in mice cross-sensitized with cannabinoid methanandamide (CAN). Our experiences with behavioral as well as immunological profiles of different cannabinoids received in our collaborative studies with Israel colleagues (Mechoulam R., Fride E.) gave rise to the present study comparing cross-sensitization with CAN to behavioral MET effects with their influences on immune function of leukocytes - phagocytic activity. Not only the behavioral sensitization to MET antiaggressive effects in aggressive singly-housed male mice on paired interactions with non-aggressive group-housed partners but also to inhibitory influence on leukocyte phagocytosis were registered in the present study when challenge doses were given several days apart from the pre-treatment with 5 daily doses of MET. In the same experimental design a cross-sensitization to the antiaggressive efficacy of methamphetamine was found after 5 daily doses of CAN. The 5 day treatment with CAN significantly increased phagocytosis of zymosan by leukocytes in vitro, and did not cross-sensitized to MET 5 challenge doses given 9 days later when the chemiluminometric curve signaling phagocytosis did not vary from the control one. These results confirm an interaction between the endocannabinoid system and MET brain mechanisms, and support further the hypothesis that repeated use of cannabis may smooth the progress of intake of psychostimulant drugs at least. Despite CA is reported as agonist with high affinity at CB1 cannabinoid receptor localized mainly in the CNS it stimulated after repeated doses leukocyte phagocytosis, but did not cross-sensitized to MET suppressive effect on this function.

Česky

Byly potvrzeny funkční interakce mezi endokanabinboidním systémem a farmakologickými mechanismy metamfetaminu v obou studovaných parametrech.

Citovat

ŠULCOVÁ, Alexandra a Leoš LANDA. Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice. In MECHOULAM, Raphael. Abstracts - NIDA International Forum 2004, San Juan, Puerto Rico. USA: US National Institute on Drug Abuse, 2004, s. 90.

@inproceedings{557327,
   author = {Šulcová, Alexandra and Landa, Leoš},
   address = {USA},
   booktitle = {Abstracts - NIDA International Forum 2004, San Juan, Puerto Rico},
   keywords = {methanandamide; methamphetamine; sensitization; mice},
   language = {eng},
   location = {USA},
   pages = {90-90},
   publisher = {US National Institute on Drug Abuse},
   title = {Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice.},
   year = {2004}
}

TY  - JOUR
ID  - 557327
AU  - Šulcová, Alexandra - Landa, Leoš
PY  - 2004
TI  - Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice.
PB  - US National Institute on Drug Abuse
CY  - USA
KW  - methanandamide
KW  - methamphetamine
KW  - sensitization
KW  - mice
N2  - The phenomenon of sensitization enhancing usually stimulant behavioral response to repeatedly administered drugs of abuse has been described both in laboratory animals and human beings. There is also data available confirming a cross-sensitization between different types of drugs of abuse supporting further the hypothesis that repeated use of one drug of abuse may facilitate the consumption of other drugs. Previously we confirmed the sensitization to methamphetamine (MET) stimulatory effect on locomotor/exploratory behavior, and also to its inhibitory influence on aggression in mice. Furthermore, such sensitization was present in mice cross-sensitized with cannabinoid methanandamide (CAN). Our experiences with behavioral as well as immunological profiles of different cannabinoids received in our collaborative studies with Israel colleagues (Mechoulam R., Fride E.) gave rise to the present study comparing cross-sensitization with CAN to behavioral MET effects with their influences on immune function of leukocytes - phagocytic activity. Not only the behavioral sensitization to MET antiaggressive effects in aggressive singly-housed male mice on paired interactions with non-aggressive group-housed partners but also to inhibitory influence on leukocyte phagocytosis were registered in the present study when challenge doses were given several days apart from the pre-treatment with 5 daily doses of MET. In the same experimental design a cross-sensitization to the antiaggressive efficacy of methamphetamine was found after 5 daily doses of CAN. The 5 day treatment with CAN significantly increased phagocytosis of zymosan by leukocytes in vitro, and did not cross-sensitized to MET 5 challenge doses given 9 days later when the chemiluminometric curve signaling phagocytosis did not vary from the control one. These results confirm an interaction between the endocannabinoid system and MET brain mechanisms, and support further the hypothesis that repeated use of cannabis may smooth the progress of intake of psychostimulant drugs at least. Despite CA is reported as agonist with high affinity at CB1 cannabinoid receptor localized mainly in the CNS it stimulated after repeated doses leukocyte phagocytosis, but did not cross-sensitized to MET suppressive effect on this function.
ER  -

ŠULCOVÁ, Alexandra a Leoš LANDA. Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice. In MECHOULAM, Raphael. \textit{Abstracts - NIDA International Forum 2004, San Juan, Puerto Rico}. USA: US National Institute on Drug Abuse, 2004, s.~90.

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