Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice

LANDA, Leoš, Karel ŠLAIS, Alexandra ŠULCOVÁ a Mariana HANESOVÁ. Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice. Psychiatrie. Praha: Tigis, 2004, roč. 8, Suppl. 4, s. 31-31. ISSN 1211-7579.

Základní údaje

Originální název

Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice

Název anglicky

Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice

Autoři

LANDA, Leoš (203 Česká republika, garant), Karel ŠLAIS (203 Česká republika), Alexandra ŠULCOVÁ (203 Česká republika) a Mariana HANESOVÁ (703 Slovensko)

Vydání

Psychiatrie, Praha, Tigis, 2004, 1211-7579

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Další údaje

Jazyk

čeština

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/04:00010276

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

behavioural sensitization; methamphetamine; memantine; open field test; mice

Štítky

behavioural sensitization, Memantine, methamphetamine, mice, open field test

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Anotace

V originále

Methamphetamine (MET) similarly to other psychostimulant drugs invokes during its repeated administration a significant increase in behavioural responses. This phenomenon is termed behavioural sensitization. There are various reports on involvement of N-methyl-D-aspartate (NMDA) receptor activity in the development and expression of behavioural sensitization, although results of them are rather controversial. Thus, the present study was designed to investigate a possible influence of NMDA receptor non-competitive antagonist memantine (MEM) on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field test.

Anglicky

Methamphetamine (MET) similarly to other psychostimulant drugs invokes during its repeated administration a significant increase in behavioural responses. This phenomenon is termed behavioural sensitization. There are various reports on involvement of N-methyl-D-aspartate (NMDA) receptor activity in the development and expression of behavioural sensitization, although results of them are rather controversial. Thus, the present study was designed to investigate a possible influence of NMDA receptor non-competitive antagonist memantine (MEM) on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field test.