The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.

LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. The influence of felbamate on sensitization to methamphetamine behavioural effects in mice. European Neuropsychopharmacology. Amsterdam: Elsevier, 2004, vol. 14, Suppl. 3, p. S346-S346, 2 pp. ISSN 0924-977X.

Basic information

Original name

The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.

Name in Czech

Vliv felbamátu na rozvoj sensitizace k behaviorálním účinkům metamfetqaminu u myší

Authors

LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic)

Edition

European Neuropsychopharmacology, Amsterdam, Elsevier, 2004, 0924-977X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.545

RIV identification code

RIV/00216224:14110/04:00010402

Organization unit

Faculty of Medicine

UT WoS

000225460400480

Keywords in English

behavioural sensitization; methamphetamine; felbamate; mice

Tags

behavioural sensitization, felbamate, methamphetamine, mice

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Abstract

V originále

Numerous studies refer to the important involvement of N-methyl-D-aspartate (NMDA) receptors in the development and expression of behavioural sensitization. Activating antiepileptic drugs of the 3rd generation, such as felbamate (FEL) also invoke psychotropic effects. They may possess attention-enhancing and antidepressant efficacy, cause anxiety, insomnia, and agitation. All pharmacological mechanisms of felbamate are not fully elucidated yet, but many of clinical effects may be related to the inhibition of NMDA currents. The present study focuses on investigation of felbamate influence on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field.We desribed prevention of expression of metamphetamine sensitization effect in the mice which received the drug challenge dose combined with felbamate.

In Czech

Výsledky potvrdily preventivní efekt felbamátu k expresi sensitizace k behaviorálním účinkům dávky metafetaminu po dané po vysazení opakového podávání této drogy.