METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND
MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY

D 2004

METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY

HADAŠOVÁ, Eva, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL, Veronika MINAŘÍKOVÁ et. al.

Základní údaje

Originální název

METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY

Název česky

Methamfetaminem indukované změny v metabolismu dextromethorfanu a midazolamu u potkanů: farmakokinetická studie

Autoři

HADAŠOVÁ, Eva (203 Česká republika, garant), Miroslav DOSTÁLEK (203 Česká republika), Jan JUŘICA (203 Česká republika), Josef TOMANDL (203 Česká republika) a Veronika MINAŘÍKOVÁ (203 Česká republika)

Vydání

Antalya (Turecko), 19th European Workshop on Drug Metabolism. Abstract & Program Book. od s. 194-194, 1 s. 2004

Nakladatel

Tubitak

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Turecko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/04:00010419

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

drug metabolism; methamphetamine; dextromethorphan; midazolam; CYP2D6; CYP3A4; pharmacokinetics;

Štítky

CYP2D6, CYP3A4, dextromethorphan, drug metabolism, methamphetamine, midazolam, pharmacokinetics

Změněno: 8. 2. 2005 13:07, doc. RNDr. Josef Tomandl, Ph.D.

Anotace

ORIG CZ

V originále

Methamphetamine (pervitine) is one of the most frequently abused substances. The drug is metabolized by the hepatic cytochromes P450, mainly by CYP2D and CYP3A. The present pharmacokinetic study in the rat investigated the possible influence of methamphetamine on metabolic fates of model substrates for CYP3A1/2 and CYP2D1/2. The pharmacokinetic analysis showed a marked stimulatory effect of methamphetamine on CYP2D1/2, as it was previously demonstrated by us in the isolated perfused rat liver. Similarly, the midazolam kinetics (marker of CYP3A1/2 activity) showed a significantly increased CYP3A-mediated metabolism. The results may have clinical impact in pharmacotherapy of methamphetamine abusers.

Česky

Methamfetaminem indukované změny v metabolismu dextromethorfanu a midazolamu u potkanů: farmakokinetická studie

Citovat

HADAŠOVÁ, Eva, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL a Veronika MINAŘÍKOVÁ. METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY. In 19th European Workshop on Drug Metabolism. Abstract & Program Book. Antalya (Turecko): Tubitak, 2004, s. 194-194.

@inproceedings{560182,
   author = {Hadašová, Eva and Dostálek, Miroslav and Juřica, Jan and Tomandl, Josef and Minaříková, Veronika},
   address = {Antalya (Turecko)},
   booktitle = {19th European Workshop on Drug Metabolism. Abstract & Program Book.},
   keywords = {drug metabolism; methamphetamine; dextromethorphan; midazolam; CYP2D6; CYP3A4; pharmacokinetics;},
   language = {eng},
   location = {Antalya (Turecko)},
   pages = {194-194},
   publisher = {Tubitak},
   title = {METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY},
   year = {2004}
}

TY  - JOUR
ID  - 560182
AU  - Hadašová, Eva - Dostálek, Miroslav - Juřica, Jan - Tomandl, Josef - Minaříková, Veronika
PY  - 2004
TI  - METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY
PB  - Tubitak
CY  - Antalya (Turecko)
KW  - drug metabolism
KW  - methamphetamine
KW  - dextromethorphan
KW  - midazolam
KW  - CYP2D6
KW  - CYP3A4
KW  - pharmacokinetics;
N2  - Methamphetamine (pervitine) is one of the most frequently abused substances. The drug is metabolized by the hepatic cytochromes P450, mainly by CYP2D and CYP3A. The present pharmacokinetic study in the rat investigated the possible influence of methamphetamine on metabolic fates of model substrates for CYP3A1/2 and CYP2D1/2. The pharmacokinetic analysis showed a marked stimulatory effect of methamphetamine on CYP2D1/2, as it was previously demonstrated by us in the isolated perfused rat liver. Similarly, the midazolam kinetics (marker of CYP3A1/2 activity) showed a significantly increased CYP3A-mediated metabolism. The results may have clinical impact in pharmacotherapy of methamphetamine abusers.
ER  -

HADAŠOVÁ, Eva, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL a Veronika MINAŘÍKOVÁ. METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY. In \textit{19th European Workshop on Drug Metabolism. Abstract \&{} Program Book.}. Antalya (Turecko): Tubitak, 2004, s.~194-194.

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