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@inproceedings{561261, author = {Pistovčáková, Jana and Šulcová, Alexandra}, address = {Portugal}, booktitle = {FENS Forum Abstracts}, edition = {vol 2}, keywords = {depression; atypical antipsychotic; sertindole; olfactory bulbectiomy; rat}, language = {eng}, location = {Portugal}, pages = {A234.4}, publisher = {Forum of European Neuroscience Societies}, title = {Sertindole has an antidepressant-like effect on behaviour and immune system in the bilaterally olfactory bulbectomized rats}, year = {2004} }
TY - JOUR ID - 561261 AU - Pistovčáková, Jana - Šulcová, Alexandra PY - 2004 TI - Sertindole has an antidepressant-like effect on behaviour and immune system in the bilaterally olfactory bulbectomized rats PB - Forum of European Neuroscience Societies CY - Portugal KW - depression KW - atypical antipsychotic KW - sertindole KW - olfactory bulbectiomy KW - rat N2 - The effects of atypical neuroleptic sertindole was studied in the rodent model of depression, the olfactory bulbectomized (OB) rat. OB rats are known to exhibit abnormal hyperactive response to a stressful situation in the open field test and alterations of the immune system functions. The open field test was performed in both sham-operated and OB rats and their locomotor activity recorded by the infra-red sensor tracking system Actitrack (Panlab, S. L., Spain). The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. In sertindol (2 mg/kg/day, 10 days i. p. ) treated OB rats a significant (p<0.05) inhibition of the OB-related hyperactivity was observed. Sertindol did not produce any sedative effect on the locomotion of the sham-operated rats. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p<0.05) by sertindol treatment (2 mg/kg/day, 10 days i. p. ). Thus, the present results confirmed an antidepressant-like impact of sertindol on both behavioural and immune parameters in the OB rat model of depression. ER -
PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Sertindole has an antidepressant-like effect on behaviour and immune system in the bilaterally olfactory bulbectomized rats. In \textit{FENS Forum Abstracts}. vol 2. Portugal: Forum of European Neuroscience Societies, 2004, s.~A234.4, 1 s.
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