Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression

PISTOVČÁKOVÁ, Jana, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL, Ivan LINHART, Alexandra ŠULCOVÁ a Eva HADAŠOVÁ. Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression. Psychiatrie. Praha: Tigis, s.r.o., 2004, roč. 8, Suppl.4, s. 39-40. ISSN 1211-7579.

Základní údaje

Originální název

Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression

Název česky

Účinek standardizovaného extraktu z třezalky na leukocytární fagocytózu v potkaním modelu deprese.

Autoři

PISTOVČÁKOVÁ, Jana (703 Slovensko), Miroslav DOSTÁLEK (203 Česká republika), Jan JUŘICA (203 Česká republika), Josef TOMANDL (203 Česká republika), Ivan LINHART (203 Česká republika), Alexandra ŠULCOVÁ (203 Česká republika) a Eva HADAŠOVÁ (203 Česká republika, garant)

Vydání

Psychiatrie, Praha, Tigis, s.r.o. 2004, 1211-7579

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/04:00010521

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

depression; Hypericum perforatum; LI160; rat; olfactory bulbectomy; immunity; leukocyte phagocytosis

Štítky

Depression, hypericum perforatum, immunity, leukocyte phagocytosis, LI160, olfactory bulbectomy, rat

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Anotace

V originále

The effects of St. Johns wort (standardized herbal extract LI 160) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat were studied. The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. The results confirm an antidepressant-like behavioural impact of LI 160 (100 mg/kg/day, 10 days i.p.) in the OB rat model of depression. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p<0.05) by LI 160 (100 mg/kg/day, 10 days i.p.). However the dose used was generally immunostimulatory active as the increase in leukocyte phagocytosis (p<0.001) was found also in the control group of rats. This immunostimulant effect of the St. Johns wort standardized extract LI 160 might be important in clinics and deserves further investigation.

Česky

The effects of St. Johns wort (standardized herbal extract LI 160) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat were studied. The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. The results confirm an antidepressant-like behavioural impact of LI 160 (100 mg/kg/day, 10 days i.p.) in the OB rat model of depression. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p<0.05) by LI 160 (100 mg/kg/day, 10 days i.p.). However the dose used was generally immunostimulatory active as the increase in leukocyte phagocytosis (p<0.001) was found also in the control group of rats. This immunostimulant effect of the St. Johns wort standardized extract LI 160 might be important in clinics and deserves further investigation.