MAREK, Radek a Vladimír SKLENÁŘ. NMR Studies of Purines. In Annual Reports on NMR Spectroscopy. London: Elsevier Ltd., 2005. s. 201-242, 41 s. 54. ISBN 0-12-505454-8. doi:10.1016/S0066-4103(04)54005-X.
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Základní údaje
Originální název NMR Studies of Purines
Název česky NMR studium purinů
Autoři MAREK, Radek (203 Česká republika, garant, domácí) a Vladimír SKLENÁŘ (203 Česká republika, domácí).
Vydání London, Annual Reports on NMR Spectroscopy, od s. 201-242, 41 s. 54, 2005.
Nakladatel Elsevier Ltd.
Další údaje
Originální jazyk angličtina
Typ výsledku Kapitola resp. kapitoly v odborné knize
Obor 10403 Physical chemistry
Stát vydavatele Velká Británie
Utajení není předmětem státního či obchodního tajemství
Forma vydání elektronická verze "online"
WWW DOI: 10.1016/S0066-4103(04)54005-X
Kód RIV RIV/00216224:14310/05:00013569
Organizační jednotka Přírodovědecká fakulta
ISBN 0-12-505454-8
UT WoS 000228553100005
Klíčová slova anglicky NMR; purines; chemical shifts; coupling constants; tautomerism; protonation; complexation
Štítky chemical shifts, Complexation, coupling constants, NMR, PROTONATION, purines, tautomerism
Změnil Změnil: prof. RNDr. Radek Marek, Ph.D., učo 381. Změněno: 25. 4. 2014 18:19.
This contribution reviews applications of NMR spectroscopy in the investigation of the structure and the intra- and intermolecular interactions of purine derivatives. Purines represent a highly important class of heterocyclic compounds that are widely distributed in all living organisms, not only as constituents of nucleic acids, but also as signal molecules. Their structure, electron distribution, and proton-transfer processes determine their chemical reactivity, interactions with solvents, and, subsequently, also their biological activity and function. Along with X-ray diffraction, NMR spectroscopy represents one of the most important experimental tools for investigating molecular topology at the atomic level. In the following text, NMR methods suitable for studying the purine structure and their application to exploring samples at natural levels of the 13C and 15N isotopes are briefly reviewed. As will be shown, isotropic 13C and 15N chemical shifts, 1H-13C one- and three-bond J-coupling constants and 1H-15N one- and two-bond couplings are the commonly used characteristic parameters for NMR in the solution state. In the solid state, CP MAS spectra of powder samples provide the principal values of the chemical-shift tensors. Quantum chemical calculations on the DFT level support and explain the experimental data. Due to the extremely wide scope of the topic, no attempt is made to cover the area completely. Rather, typical examples of applications and recently published contributions in all of the areas identified above are included to provide the reader with a summary of the current efforts to increase our knowledge and understanding of the interactions at the atomic, molecular and intermolecular level in purine and its derivatives.
Anotace česky
Tento příspěvek shrnuje aplikace NMR spektroskopie při studiu struktury, intramolekulárních a intermolekulárních interakcí derivátů purinu.
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Biomolekulární centrum
VytisknoutZobrazeno: 27. 11. 2022 05:54