Comparison of the role of 5-HT1 and 5-HT2 receptors in the
regulation of locomotor/exploratory behaviour in rats

J 2004

Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats

NOVÁKOVÁ, Jana a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats

Název česky

Porovnání úlohy receptorů 5-HT1 a 5-HT2 v regulaci lokomočně-pátracího chování potaknů

Autoři

NOVÁKOVÁ, Jana a Alexandra ŠULCOVÁ

Vydání

Homeostasis, Milano, Italy, C.I.A.N.S. 2004, 0960-7560

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/04:00010698

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

serotonin-5-HT1 and 5-HT2 receptor ligands-locomotor/exploratory behaviour-rats

Změněno: 24. 3. 2006 12:55, prof. MUDr. Alexandra Šulcová, CSc.

Anotace

ORIG CZ

V originále

The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activities of animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/exploratory behaviour in animals and such observations should be of significance to experimental and clinical studies of the influence of 5-HT1A agonists upon depressive and anxiety disorders.

Česky

Výsledky ukázaly na významnou roli 5-HT1 receptorového systému v regulacích lokomočně-pátrací aktivity potkanů.

Návaznosti

GP305/02/D130, projekt VaV

Název: Funkční úloha serotoninového 5-HT2 receptorového podtypu při rozvoji závislosti na metamfetamin

Investor: Grantová agentura ČR, Funkční úloha serotoninového 5-HT2 receptorového podtypu při rozvoji závislosti na metamfetamin

Citovat

NOVÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats. Homeostasis. Milano, Italy: C.I.A.N.S., 2004, roč. 43, č. 1, s. 46-48. ISSN 0960-7560.

@article{562911,
   author = {Nováková, Jana and Šulcová, Alexandra},
   article_location = {Milano, Italy},
   article_number = {1},
   keywords = {serotonin-5-HT1 and 5-HT2 receptor ligands-locomotor/exploratory behaviour-rats},
   language = {eng},
   issn = {0960-7560},
   journal = {Homeostasis},
   title = {Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats},
   volume = {43},
   year = {2004}
}

TY  - JOUR
ID  - 562911
AU  - Nováková, Jana - Šulcová, Alexandra
PY  - 2004
TI  - Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats
JF  - Homeostasis
VL  - 43
IS  - 1
SP  - 46-48
EP  - 46-48
PB  - C.I.A.N.S.
SN  - 09607560
KW  - serotonin-5-HT1 and 5-HT2 receptor ligands-locomotor/exploratory behaviour-rats
N2  - The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activities of animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/exploratory behaviour in animals and such observations should be of significance to experimental and clinical studies of the influence of 5-HT1A agonists upon depressive and anxiety disorders.
ER  -

NOVÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats. \textit{Homeostasis}. Milano, Italy: C.I.A.N.S., 2004, roč.~43, č.~1, s.~46-48. ISSN~0960-7560.

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