Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a
marker for cutaneous T-cell lymphoma (CTCL)

J 2004

Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)

VAŠKŮ, Julie, Anna VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ a Vladimír VAŠKŮ

Základní údaje

Originální název

Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)

Název česky

Heterozygot AG polymorfismu -596 A/G v genu pro IL-6 je marker pro kožní T-lymfom (CTCL)

Autoři

VAŠKŮ, Julie (203 Česká republika, garant), Anna VAŠKŮ (203 Česká republika), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika) a Vladimír VAŠKŮ (203 Česká republika)

Vydání

Clinical Immunology, USA, Elsevier Inc. 2004, 1521-6616

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.034

Kód RIV

RIV/00216224:14110/04:00010704

Organizační jednotka

Lékařská fakulta

UT WoS

000224975700007

Klíčová slova anglicky

CTCL; IL-6; Gene polymorphism; Marker

Štítky

CTCL, Gene polymorphism, IL-6, marker

Změněno: 18. 6. 2009 09:16, prof. MUDr. Anna Vašků, CSc.

Anotace

ORIG CZ

V originále

The aim of the study was to investigate possible associations of IL-6 gene polymorphisms (596 A/G and 174 C/G) with cutaneous T-cell lymphoma (CTCL). In the case-control study, genotype distributions and allelic frequencies in two promoter IL-6 gene polymorphisms in the group of 63 Czech patients with CTCL were compared to those of 105 control non-CTCL subjects matched for aged and sex. The IL-6 gene polymorphisms were determined by PCR with following restriction analysis. A significant difference of 596 A/G IL-6 genotype distribution was found between the CTCL patients and the controls (P=0.002) with almost threefold odds ratio for the heterozygote (AG) genotype in CTCL patients (OR=2.64, P=0.002). No significant differences in genotype distribution and/or allelic frequency of functional -174C/G IL-6 gene polymorphism were observed. The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with CTCL (OR=2.24, 95% confidence interval 1.17-4.28, P=0.01). Thus, the heterozygote variant of -596A/G promoter IL-6 polymorphism could be considered as a genotype marker for CTCL .

Česky

Prokázali jsme signifikantní rozdíl v distribuci genotypu -596 A/G IL-6 mezi pacienty s CTCL a kontrolami (P=0,002) s téměř trojnásobným odds ratio pro heterozygotní genotyp AG u pacientů s CTCL orpoti kontrolám (OR=2,64, P=0,002).

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Julie, Anna VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ a Vladimír VAŠKŮ. Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL). Clinical Immunology. USA: Elsevier Inc., 2004, roč. 113, č. 3, s. 256-260. ISSN 1521-6616.

@article{562944,
   author = {Vašků, Julie and Vašků, Anna and Pávková Goldbergová, Monika and Vašků, Vladimír},
   article_location = {USA},
   article_number = {3},
   keywords = {CTCL; IL-6; Gene polymorphism; Marker},
   language = {eng},
   issn = {1521-6616},
   journal = {Clinical Immunology},
   title = {Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)},
   url = {www.sciencedirect.com},
   volume = {113},
   year = {2004}
}

TY  - JOUR
ID  - 562944
AU  - Vašků, Julie - Vašků, Anna - Pávková Goldbergová, Monika - Vašků, Vladimír
PY  - 2004
TI  - Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)
JF  - Clinical Immunology
VL  - 113
IS  - 3
SP  - 256-260
EP  - 256-260
PB  - Elsevier Inc.
SN  - 15216616
KW  - CTCL
KW  - IL-6
KW  - Gene polymorphism
KW  - Marker
UR  - www.sciencedirect.com
N2  - The aim of the study was to investigate possible associations of IL-6 gene polymorphisms (596 A/G and 174 C/G) with cutaneous T-cell lymphoma (CTCL). In the case-control study, genotype distributions and allelic frequencies in two promoter IL-6 gene polymorphisms in the group of 63 Czech patients with CTCL were compared to those of 105 control non-CTCL subjects matched for aged and sex. The IL-6 gene polymorphisms were determined by PCR with following restriction analysis. A significant difference of 596 A/G IL-6 genotype distribution was found between the CTCL patients and the controls (P=0.002) with almost threefold odds ratio for the heterozygote (AG) genotype in CTCL patients (OR=2.64, P=0.002). No significant differences in genotype distribution and/or allelic frequency of functional -174C/G IL-6 gene polymorphism were observed. The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with CTCL (OR=2.24, 95% confidence interval 1.17-4.28, P=0.01). Thus, the heterozygote variant of -596A/G promoter IL-6 polymorphism could be considered as a genotype marker for CTCL .
ER  -

VAŠKŮ, Julie, Anna VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ a Vladimír VAŠKŮ. Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL). \textit{Clinical Immunology}. USA: Elsevier Inc., 2004, roč.~113, č.~3, s.~256-260. ISSN~1521-6616.

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